Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis

Robert L. Keith, Mark W. Geraci, S. Patrick Nana-Sinkam, Richard M. Breyer, Tyler M. Hudish, Amy M. Meyer, Alvin M. Malkinson, Lori D. Dwyer-Nield

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Manipulating prostaglandin (PG) production modulates tumor development. Elevated PGI2 production prevents murine lung cancer, while decreasing PGE2 content protects against colon cancer. PGE 2 receptor subtype 2 (EP2)-deficient mice were hypothesized to be resistant to lung tumorigenesis. Materials and Methods: EP2 null BALB/c mice and their wild-type littermates were exposed to an initiationpromotion carcinogenesis protocol and lung tumorigenesis was examined. Chronic lung inflammation was induced to determine whether EP 2 ablation influenced inflammatory cell infiltration. Results: Tumor multiplicity in EP2 null mice was 34% lower than in their wild-type littermates (21.9±3.0 vs. 14.5±2.9 tumors/mouse, p2, acting through EP2, enhanced lung tumorigenesis through a mechanism that may be distinct from its proinflammatory activity. Thus, EP2 is a potential target for novel chemoprevention strategies.

Original languageEnglish (US)
Pages (from-to)2857-2861
Number of pages5
JournalAnticancer Research
Volume26
Issue number4 B
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Prostaglandin Receptors
Dinoprostone
Carcinogenesis
Lung
Prostaglandin E Receptors
Neoplasms
Chemoprevention
Epoprostenol
Colonic Neoplasms
Prostaglandins
Lung Neoplasms
Pneumonia

Keywords

  • Chronic pulmonary inflammation
  • Downstream prostaglandin receptors
  • EP
  • Two-stage carcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Keith, R. L., Geraci, M. W., Nana-Sinkam, S. P., Breyer, R. M., Hudish, T. M., Meyer, A. M., ... Dwyer-Nield, L. D. (2006). Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis. Anticancer Research, 26(4 B), 2857-2861.

Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis. / Keith, Robert L.; Geraci, Mark W.; Nana-Sinkam, S. Patrick; Breyer, Richard M.; Hudish, Tyler M.; Meyer, Amy M.; Malkinson, Alvin M.; Dwyer-Nield, Lori D.

In: Anticancer Research, Vol. 26, No. 4 B, 07.2006, p. 2857-2861.

Research output: Contribution to journalArticle

Keith, RL, Geraci, MW, Nana-Sinkam, SP, Breyer, RM, Hudish, TM, Meyer, AM, Malkinson, AM & Dwyer-Nield, LD 2006, 'Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis', Anticancer Research, vol. 26, no. 4 B, pp. 2857-2861.
Keith RL, Geraci MW, Nana-Sinkam SP, Breyer RM, Hudish TM, Meyer AM et al. Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis. Anticancer Research. 2006 Jul;26(4 B):2857-2861.
Keith, Robert L. ; Geraci, Mark W. ; Nana-Sinkam, S. Patrick ; Breyer, Richard M. ; Hudish, Tyler M. ; Meyer, Amy M. ; Malkinson, Alvin M. ; Dwyer-Nield, Lori D. / Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis. In: Anticancer Research. 2006 ; Vol. 26, No. 4 B. pp. 2857-2861.
@article{0a879f7af0fd422fafe5a6d5d007b197,
title = "Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis",
abstract = "Background: Manipulating prostaglandin (PG) production modulates tumor development. Elevated PGI2 production prevents murine lung cancer, while decreasing PGE2 content protects against colon cancer. PGE 2 receptor subtype 2 (EP2)-deficient mice were hypothesized to be resistant to lung tumorigenesis. Materials and Methods: EP2 null BALB/c mice and their wild-type littermates were exposed to an initiationpromotion carcinogenesis protocol and lung tumorigenesis was examined. Chronic lung inflammation was induced to determine whether EP 2 ablation influenced inflammatory cell infiltration. Results: Tumor multiplicity in EP2 null mice was 34{\%} lower than in their wild-type littermates (21.9±3.0 vs. 14.5±2.9 tumors/mouse, p2, acting through EP2, enhanced lung tumorigenesis through a mechanism that may be distinct from its proinflammatory activity. Thus, EP2 is a potential target for novel chemoprevention strategies.",
keywords = "Chronic pulmonary inflammation, Downstream prostaglandin receptors, EP, Two-stage carcinogenesis",
author = "Keith, {Robert L.} and Geraci, {Mark W.} and Nana-Sinkam, {S. Patrick} and Breyer, {Richard M.} and Hudish, {Tyler M.} and Meyer, {Amy M.} and Malkinson, {Alvin M.} and Dwyer-Nield, {Lori D.}",
year = "2006",
month = "7",
language = "English (US)",
volume = "26",
pages = "2857--2861",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4 B",

}

TY - JOUR

T1 - Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis

AU - Keith, Robert L.

AU - Geraci, Mark W.

AU - Nana-Sinkam, S. Patrick

AU - Breyer, Richard M.

AU - Hudish, Tyler M.

AU - Meyer, Amy M.

AU - Malkinson, Alvin M.

AU - Dwyer-Nield, Lori D.

PY - 2006/7

Y1 - 2006/7

N2 - Background: Manipulating prostaglandin (PG) production modulates tumor development. Elevated PGI2 production prevents murine lung cancer, while decreasing PGE2 content protects against colon cancer. PGE 2 receptor subtype 2 (EP2)-deficient mice were hypothesized to be resistant to lung tumorigenesis. Materials and Methods: EP2 null BALB/c mice and their wild-type littermates were exposed to an initiationpromotion carcinogenesis protocol and lung tumorigenesis was examined. Chronic lung inflammation was induced to determine whether EP 2 ablation influenced inflammatory cell infiltration. Results: Tumor multiplicity in EP2 null mice was 34% lower than in their wild-type littermates (21.9±3.0 vs. 14.5±2.9 tumors/mouse, p2, acting through EP2, enhanced lung tumorigenesis through a mechanism that may be distinct from its proinflammatory activity. Thus, EP2 is a potential target for novel chemoprevention strategies.

AB - Background: Manipulating prostaglandin (PG) production modulates tumor development. Elevated PGI2 production prevents murine lung cancer, while decreasing PGE2 content protects against colon cancer. PGE 2 receptor subtype 2 (EP2)-deficient mice were hypothesized to be resistant to lung tumorigenesis. Materials and Methods: EP2 null BALB/c mice and their wild-type littermates were exposed to an initiationpromotion carcinogenesis protocol and lung tumorigenesis was examined. Chronic lung inflammation was induced to determine whether EP 2 ablation influenced inflammatory cell infiltration. Results: Tumor multiplicity in EP2 null mice was 34% lower than in their wild-type littermates (21.9±3.0 vs. 14.5±2.9 tumors/mouse, p2, acting through EP2, enhanced lung tumorigenesis through a mechanism that may be distinct from its proinflammatory activity. Thus, EP2 is a potential target for novel chemoprevention strategies.

KW - Chronic pulmonary inflammation

KW - Downstream prostaglandin receptors

KW - EP

KW - Two-stage carcinogenesis

UR - http://www.scopus.com/inward/record.url?scp=33746710377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746710377&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 2857

EP - 2861

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4 B

ER -