Prostaglandin production was studied in fetal and adult type II alveolar epithelial cells. Two culture systems were employed, fetal rat lung organotypic cultures consisting of fetal type II cells and monolayer cultures of adult lung type II cells. Dexamethasone, thyroxine, prolactin and insulin, hormones which influence lung development, each reduced the production of prostaglandin E and Fα by the organotypic cultures. The fetal cultures produced relatively large quantities of prostaglandin E and Fα and smaller quantities of 6-keto-prosta-glandin F1α and thromboxane B2. However, prostaglandin E2 production was predominant. In contrast, the adult type II cells in monolayer culture produced predominantly prostacyclin (6-keto-prostaglandin F1a) along with smaller quantities of prostaglandin E2 and F2α. The type II cells were relatively unresponsive to prostaglandins. Exogenously added prostaglandin E2 had no effect on cell growth, and only a minimal effect on cyclic AMP levels in the monolayer cultures.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism|
|State||Published - Mar 29 1979|
- (Alveolar epithelium)
- Prostaglandin synthesis
ASJC Scopus subject areas