Prostaglandin production by type II alveolar epithelial cells

Linda Taylor, Peter Polgar, James A. McAteer, William H.J. Douglas

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Prostaglandin production was studied in fetal and adult type II alveolar epithelial cells. Two culture systems were employed, fetal rat lung organotypic cultures consisting of fetal type II cells and monolayer cultures of adult lung type II cells. Dexamethasone, thyroxine, prolactin and insulin, hormones which influence lung development, each reduced the production of prostaglandin E and Fα by the organotypic cultures. The fetal cultures produced relatively large quantities of prostaglandin E and Fα and smaller quantities of 6-keto-prosta-glandin F and thromboxane B2. However, prostaglandin E2 production was predominant. In contrast, the adult type II cells in monolayer culture produced predominantly prostacyclin (6-keto-prostaglandin F1a) along with smaller quantities of prostaglandin E2 and F. The type II cells were relatively unresponsive to prostaglandins. Exogenously added prostaglandin E2 had no effect on cell growth, and only a minimal effect on cyclic AMP levels in the monolayer cultures.

Original languageEnglish (US)
Pages (from-to)502-509
Number of pages8
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume572
Issue number3
DOIs
StatePublished - Mar 29 1979

Keywords

  • (Alveolar epithelium)
  • Prostaglandin synthesis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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