Prostate cancer

From Gleason scoring to prognostic grade grouping

Rodolfo Montironi, Matteo Santoni, Roberta Mazzucchelli, Luciano Burattini, Rossana Berardi, Andrea B. Galosi, Liang Cheng, Antonio Lopez-Beltran, Alberto Briganti, Francesco Montorsi, Marina Scarpelli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.

Original languageEnglish (US)
Pages (from-to)433-440
Number of pages8
JournalExpert Review of Anticancer Therapy
Volume16
Issue number4
DOIs
StatePublished - Apr 2 2016

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Prostatic Neoplasms
Adenocarcinoma
Neoplasm Grading
Surgical Pathology
Pathology
Technology

Keywords

  • 2005 ISUP Gleason modified system
  • 2014 ISUP Gleason modified system
  • Gleason grading
  • International society of urological pathology
  • prognostic grade grouping
  • Prostate cancer

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

Cite this

Montironi, R., Santoni, M., Mazzucchelli, R., Burattini, L., Berardi, R., Galosi, A. B., ... Scarpelli, M. (2016). Prostate cancer: From Gleason scoring to prognostic grade grouping. Expert Review of Anticancer Therapy, 16(4), 433-440. https://doi.org/10.1586/14737140.2016.1160780

Prostate cancer : From Gleason scoring to prognostic grade grouping. / Montironi, Rodolfo; Santoni, Matteo; Mazzucchelli, Roberta; Burattini, Luciano; Berardi, Rossana; Galosi, Andrea B.; Cheng, Liang; Lopez-Beltran, Antonio; Briganti, Alberto; Montorsi, Francesco; Scarpelli, Marina.

In: Expert Review of Anticancer Therapy, Vol. 16, No. 4, 02.04.2016, p. 433-440.

Research output: Contribution to journalArticle

Montironi, R, Santoni, M, Mazzucchelli, R, Burattini, L, Berardi, R, Galosi, AB, Cheng, L, Lopez-Beltran, A, Briganti, A, Montorsi, F & Scarpelli, M 2016, 'Prostate cancer: From Gleason scoring to prognostic grade grouping', Expert Review of Anticancer Therapy, vol. 16, no. 4, pp. 433-440. https://doi.org/10.1586/14737140.2016.1160780
Montironi R, Santoni M, Mazzucchelli R, Burattini L, Berardi R, Galosi AB et al. Prostate cancer: From Gleason scoring to prognostic grade grouping. Expert Review of Anticancer Therapy. 2016 Apr 2;16(4):433-440. https://doi.org/10.1586/14737140.2016.1160780
Montironi, Rodolfo ; Santoni, Matteo ; Mazzucchelli, Roberta ; Burattini, Luciano ; Berardi, Rossana ; Galosi, Andrea B. ; Cheng, Liang ; Lopez-Beltran, Antonio ; Briganti, Alberto ; Montorsi, Francesco ; Scarpelli, Marina. / Prostate cancer : From Gleason scoring to prognostic grade grouping. In: Expert Review of Anticancer Therapy. 2016 ; Vol. 16, No. 4. pp. 433-440.
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