Prostate Cancer Old Problems and New Approaches - Part II. Diagnostic and Prognostic Markers, Pathology and Biological Aspects

Kenneth V. Honn, Amer Aref, Yong Q. Chen, Miehael L. Cher, John D. Crissman, Jeffrey D. Forman, Xiang Gao, David Grignon, Maha Hussain, Arthur T. Porter, J. Edson Pontes, Isaae Powell, Bruce Redman, Wael Sakr, Richard Severson, Dean G. Tang, David P. Wood

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Diagnostic and prognostic markers for prostatic cancer (PCa) include conventional protein markers (e.g., PAP, PSA, PSMA, PIP, OA-519, Ki-67, PCNA, TF, collagenase, and TIMP 1), angiogenesis indicator (e.g., factor VIII), neuroendocrine differentiation status, adhesion molecules (E-cadherin, integrin), bone matrix degrading products (e.g., ICPT), as well as molecular markers (e.g., PSA, PSMA, p53, 12LOX, and MSI). Currently, only PSA is used clinically for early diagnosis and monitoring of PCa. The histological differential diagnosis of prostatic adenocarcinoma includes normal tissues such as Cowper's gland, Paraganglion tissue and seminal vesicle or ejaculatory duct as well as pathological conditions such as atypical adenomatous hyperplasia, atrophy, basal cell hyperplasia and sclerosing adenosis. A common PCa is characterized by a remarkable heterogeneity in terms of its differentiation, microscopic growth patterns and biological aggressiveness. Most PCa are multifocal with signi ficant variations in tumor grade between anatomically separated tumor foci. The Gleason grading system which recognizes five major grades defined by patterns of neoplastic growth has gained almost uniform acceptance. In predicting the biologic behavior of PCa clinical and pathological stages are used as the major prognostic indicators. Among the cell proliferation and death regulators androgens are critical survival factors for normal prostate epithelial cells as well as for the androgen-dependent human prostatic cancer cells. The androgen ablation has been shown to increase the apoptotic index in prostatic cancer patients and castration also promotes apoptotic death of human prostate carcinoma grown in mice. The progression of PCa, similarly to other malignancies, is a multistep process, accompanied by genetic and epigenetic changes, involving phenomenons as adhesion, invasion and angiogenesis (without prostate specific features).

Original languageEnglish (US)
Pages (from-to)191-211
Number of pages21
JournalPathology & Oncology Research
Volume2
Issue number3
DOIs
StatePublished - Sep 1 1996

Keywords

  • biology
  • diagnosis
  • pathology
  • prognosis
  • prostate cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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    Honn, K. V., Aref, A., Chen, Y. Q., Cher, M. L., Crissman, J. D., Forman, J. D., Gao, X., Grignon, D., Hussain, M., Porter, A. T., Pontes, J. E., Powell, I., Redman, B., Sakr, W., Severson, R., Tang, D. G., & Wood, D. P. (1996). Prostate Cancer Old Problems and New Approaches - Part II. Diagnostic and Prognostic Markers, Pathology and Biological Aspects. Pathology & Oncology Research, 2(3), 191-211. https://doi.org/10.1007/BF02903527