Prostate cancer risk in U.S. blacks and whites with a family history of cancer

R. B. Hayes, J. M. Liff, L. M. Pottern, R. S. Greenberg, J. B. Schoenberg, A. G. Schwartz, G. M. Swanson, D. T. Silverman, L. Morris Brown, R. N. Hoover, J. F. Fraumeni

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Prostate cancer occurs more frequently in U.S. blacks than whites. A population-based case-control study which investigated the association with family history of cancer was carried out among 981 men (479 black, 502 white) with pathologically confirmed prostate cancer, diagnosed between August 1, 1986, and April 30, 1989, and 1,315 controls (594 black, 721 white). Study subjects, aged 40-79, resided in Atlanta, Detroit, and 10 counties in New Jersey, geographic areas covered by population-based cancer registries. Prostate cancer risk was significantly elevated among those who reported a history of prostate cancer in first-degree relatives (O.R. =3.2; 95% C.I.: 2.0-5.0), with blacks and whites having similarly elevated risks. These risks were unchanged by statistical adjustment for job-related socio-economic status, education, income, and marital status. Overall, the ORs associated with history of prostate cancer in fathers and brothers were 2.5 (95% C.I.: 1.5-4.2) and 5.3 (95% C.I.: 2.3-12.5), respectively. Risks associated with a family history of prostate cancer were consistently elevated among younger and older subjects. Only small non-significant excesses of prostate cancer risk were associated with a family history of breast, colorectal, or other cancers. While familial occurrence is a key risk factor for prostate cancer and likely to be genetically based, the similar familial risks among blacks and whites suggest that the ethnic disparity in incidence is influenced by environmental factors.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalInternational Journal of Cancer
Volume60
Issue number3
StatePublished - 1995
Externally publishedYes

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Prostatic Neoplasms
Neoplasms
hydroquinone
Marital Status
Fathers
Population
Registries
Case-Control Studies
Siblings
Breast
Economics
Education
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hayes, R. B., Liff, J. M., Pottern, L. M., Greenberg, R. S., Schoenberg, J. B., Schwartz, A. G., ... Fraumeni, J. F. (1995). Prostate cancer risk in U.S. blacks and whites with a family history of cancer. International Journal of Cancer, 60(3), 361-364.

Prostate cancer risk in U.S. blacks and whites with a family history of cancer. / Hayes, R. B.; Liff, J. M.; Pottern, L. M.; Greenberg, R. S.; Schoenberg, J. B.; Schwartz, A. G.; Swanson, G. M.; Silverman, D. T.; Morris Brown, L.; Hoover, R. N.; Fraumeni, J. F.

In: International Journal of Cancer, Vol. 60, No. 3, 1995, p. 361-364.

Research output: Contribution to journalArticle

Hayes, RB, Liff, JM, Pottern, LM, Greenberg, RS, Schoenberg, JB, Schwartz, AG, Swanson, GM, Silverman, DT, Morris Brown, L, Hoover, RN & Fraumeni, JF 1995, 'Prostate cancer risk in U.S. blacks and whites with a family history of cancer', International Journal of Cancer, vol. 60, no. 3, pp. 361-364.
Hayes RB, Liff JM, Pottern LM, Greenberg RS, Schoenberg JB, Schwartz AG et al. Prostate cancer risk in U.S. blacks and whites with a family history of cancer. International Journal of Cancer. 1995;60(3):361-364.
Hayes, R. B. ; Liff, J. M. ; Pottern, L. M. ; Greenberg, R. S. ; Schoenberg, J. B. ; Schwartz, A. G. ; Swanson, G. M. ; Silverman, D. T. ; Morris Brown, L. ; Hoover, R. N. ; Fraumeni, J. F. / Prostate cancer risk in U.S. blacks and whites with a family history of cancer. In: International Journal of Cancer. 1995 ; Vol. 60, No. 3. pp. 361-364.
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