Prostate Size is Associated With Surgical Difficulty but Not Functional Outcome at 1 Year After Radical Prostatectomy

Joseph A. Pettus, Timothy Masterson, Alexander Sokol, Angel M. Cronin, Caroline Savage, Jaspreet S. Sandhu, John P. Mulhall, Peter T. Scardino, Farhang Rabbani

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose: We assessed the impact of prostate size on operative difficulty as measured by estimated blood loss, operating room time and positive surgical margins. In addition, we assessed the impact on biochemical recurrence and the functional outcomes of potency and continence at 1 year after radical prostatectomy as well as postoperative bladder neck contracture. Materials and Methods: From 1998 to 2007, 3,067 men underwent radical prostatectomy by 1 of 5 dedicated prostate surgeons with no neoadjuvant or adjuvant therapy. Pathological specimen weight was used as a measure of prostate size. Cox proportional hazards and logistic regression analysis was used to study the association between specimen weight, and biochemical recurrence and surgical margin status, respectively, controlling for adverse pathological features. Continence and potency were analyzed controlling for age, nerve sparing status and surgical approach. Results: With increasing prostate size there was increased estimated blood loss (p = 0.013) and operative time (p = 0.004), and a decrease in positive surgical margins (84 of 632 [14%] for 40 gm or less, 99 of 862 [12%] for 41 to 50 gm, 78 of 842 [10%] for 51 to 65 gm, 68 of 731 [10%] for more than 65 gm, p

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalJournal of Urology
Volume182
Issue number3
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Prostatectomy
Prostate
Weights and Measures
Recurrence
Contracture
Operating Rooms
Operative Time
Urinary Bladder
Logistic Models
Regression Analysis
Margins of Excision
Therapeutics

Keywords

  • organ size
  • outcome assessment (health care)
  • penile erection
  • prostatectomy
  • urinary incontinence

ASJC Scopus subject areas

  • Urology

Cite this

Prostate Size is Associated With Surgical Difficulty but Not Functional Outcome at 1 Year After Radical Prostatectomy. / Pettus, Joseph A.; Masterson, Timothy; Sokol, Alexander; Cronin, Angel M.; Savage, Caroline; Sandhu, Jaspreet S.; Mulhall, John P.; Scardino, Peter T.; Rabbani, Farhang.

In: Journal of Urology, Vol. 182, No. 3, 09.2009, p. 949-955.

Research output: Contribution to journalArticle

Pettus, JA, Masterson, T, Sokol, A, Cronin, AM, Savage, C, Sandhu, JS, Mulhall, JP, Scardino, PT & Rabbani, F 2009, 'Prostate Size is Associated With Surgical Difficulty but Not Functional Outcome at 1 Year After Radical Prostatectomy', Journal of Urology, vol. 182, no. 3, pp. 949-955. https://doi.org/10.1016/j.juro.2009.05.029
Pettus, Joseph A. ; Masterson, Timothy ; Sokol, Alexander ; Cronin, Angel M. ; Savage, Caroline ; Sandhu, Jaspreet S. ; Mulhall, John P. ; Scardino, Peter T. ; Rabbani, Farhang. / Prostate Size is Associated With Surgical Difficulty but Not Functional Outcome at 1 Year After Radical Prostatectomy. In: Journal of Urology. 2009 ; Vol. 182, No. 3. pp. 949-955.
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