Prostatic xanthoma

A mimic of prostatic adenocarcinoma

Thomas J. Sebo, David G. Bostwick, George M. Farrow, John Eble

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Xanthoma is a localized collection of cholesterol-laden histiocytes that is usually idiopathic, but may be seen in patients with hyperlipidemia. We report seven cases of xanthoma involving the prostate, including one arising in a patient with mild hyperlipidemia. Prostatic xanthoma appeared as a solitary microscopic lesion in the peripheral zone (six cases) or transition zone (one case). One needle biopsy specimen with xanthoma was initially interpreted as well-differentiated adenocarcinoma with a clear cell (hypernephroid) pattern, but immunohistochemical studies revealed the histiocytic nature of the proliferation. Five cases (three needle biopsy specimens and two retropubic prostatectomy specimens) contained a solitary xanthoma adjacent to foci of adenocarcinoma. Another xanthoma was present in a transurethral resection specimen with nodular hyperplasia. Although unusual, xanthoma should be considered in the differential diagnosis of clear cell adenocarcinoma and other clear cell proliferations of the prostate, particularly in limited tissue samples, such as from needle biopsies and transurethral resections.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalHuman Pathology
Volume25
Issue number4
DOIs
StatePublished - 1994

Fingerprint

Xanthomatosis
Adenocarcinoma
Needle Biopsy
Hyperlipidemias
Prostate
Clear Cell Adenocarcinoma
Histiocytes
Prostatectomy
Hyperplasia
Differential Diagnosis
Cholesterol
Cell Proliferation

Keywords

  • carcinoma
  • granulomatous
  • prostate
  • prostatitis
  • xanthoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prostatic xanthoma : A mimic of prostatic adenocarcinoma. / Sebo, Thomas J.; Bostwick, David G.; Farrow, George M.; Eble, John.

In: Human Pathology, Vol. 25, No. 4, 1994, p. 386-389.

Research output: Contribution to journalArticle

Sebo, Thomas J. ; Bostwick, David G. ; Farrow, George M. ; Eble, John. / Prostatic xanthoma : A mimic of prostatic adenocarcinoma. In: Human Pathology. 1994 ; Vol. 25, No. 4. pp. 386-389.
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