Prosthetic replacement for the thoracic vena cava. An experimental study

A. C. Fiore, J. W. Brown, R. S. Cromartie, L. C. Ofstein, P. S. Peigh, N. S. Sears, W. P. Deschner, H. King

Research output: Contribution to journalArticle

31 Scopus citations


The superior vena cava (SVC) and thoracic inferior vena cava (IVC) were replaced in 46 dogs with autologous vein, knitted Dacron, glutaraldehyde-fixed porcine pericardium, unsupported polytetrafluoroethylene (PTFE), and externally stented PTFE. After 30 days, patency rates were determined by contrast venography and were 100%, 0%, 50%, 75%, and 100%, respectively. The patency rates of Dacron and glutaraldehyde-fixed pericardium are considered unacceptable when compared to autologous vein (p < 0.05). Stented PTFE exhibited a patency rate equal to that of autologous vein at 30 days, minimal graft reaction, excellent incorporation by host fibroblasts, and a smooth neointima. The external spiral support added to PTFE enhanced the thromboresistance of this graft in the thoracic venous system. Long-term follow-up is required to determine if the stented PTFE prosthesis remains comparable to autologous vein as a venous conduit.

Original languageEnglish (US)
Pages (from-to)560-568
Number of pages9
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number4
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Fiore, A. C., Brown, J. W., Cromartie, R. S., Ofstein, L. C., Peigh, P. S., Sears, N. S., Deschner, W. P., & King, H. (1982). Prosthetic replacement for the thoracic vena cava. An experimental study. Journal of Thoracic and Cardiovascular Surgery, 84(4), 560-568.