Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase

Rebeccah S. Lijek, Santiago L. Luque, Qian Liu, Dane Parker, Taeok Bae, Jeffrey N. Weiser

Research output: Contribution to journalArticle

29 Scopus citations


Nasal colonization by Staphylococcus aureus is the major risk factor for disease and transmission. Epidemiological studies have reported a reduced risk of S. aureus carriage in immunocompetent but not in immunocompromised children colonized by Streptococcus pneumoniae. We investigate the hypothesis that the immune response to pneumococcal colonization affects S. aureus colonization. We demonstrate that pneumococcal colonization in mice inhibits subsequent S. aureus acquisition in an antibody-dependent manner and elicits antibody that cross-reacts with S. aureus. We identify the staphylococcal target of cross-reactive antibody as 1-pyrroline- 5-carboxylate dehydrogenase (P5CDH), and the homologous immunogen in S. pneumoniae as SP-1119, both of which are conserved dehydrogenases. These antigens are necessary and sufficient to inhibit the acquisition of S. aureus colonization in a mouse model. Our findings demonstrate that immune-mediated cross-reactivity between S. pneumoniae and S. aureus protects against S. aureus nasal acquisition and thus reveal a paradigm for identifying protective antigens against S. aureus.

Original languageEnglish (US)
Pages (from-to)13823-13828
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number34
StatePublished - Aug 21 2012



  • Methicillin-resistant S. Aureus
  • Pneumococcus
  • Vaccine

ASJC Scopus subject areas

  • General

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