Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) Is dependent on extract composition

Laura Wright, Jennifer B. Frye, Barbara N. Timmermann, Janet L. Funk

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague-Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60 mg/kg 3×per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy X-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by microcomputerized tomography (μCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor.

Original languageEnglish (US)
Pages (from-to)9498-9504
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume58
Issue number17
DOIs
StatePublished - Sep 8 2010
Externally publishedYes

Fingerprint

Curcuma
Curcuma longa
turmeric
Rats
Bone
bones
rats
extracts
Chemical analysis
Bone and Bones
protective effect
Zingiberaceae
Weights and Measures
Postmenopausal Osteoporosis
dual-energy X-ray absorptiometry
tomography
osteoporosis
Photon Absorptiometry
bone density
femur

Keywords

  • bone μCT
  • bone mineral density
  • Curcuma longa L.
  • curcuminoids
  • ovariectomy
  • Turmeric

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) Is dependent on extract composition. / Wright, Laura; Frye, Jennifer B.; Timmermann, Barbara N.; Funk, Janet L.

In: Journal of Agricultural and Food Chemistry, Vol. 58, No. 17, 08.09.2010, p. 9498-9504.

Research output: Contribution to journalArticle

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