Protective roles of CNS mitochondria

Janet M. Dubinsky, Nickolay Brustovetsky, Reghann LaFrance

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Mitochondria benefit their host cells by generating ATP, detoxifying oxygen, maintaining cellular redox potential, and detoxifying reactive oxygen species and xenobiotics. These beneficial roles are in stark contrast to mitochondrial participation in both necrotic and apoptotic degenerative pathways. However, cellular stresses do not always result in deleterious mitochondrial changes. Decreases in the calcium sensitivity of the permeability transition may be initial mitochondrial responses to stress that act to preserve mitochondrial function and prolong normal functioning of the host cell.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalJournal of Bioenergetics and Biomembranes
Volume36
Issue number4 SPEC.ISS.
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

Keywords

  • Huntington's disease
  • Permeability transition
  • calcium sensitivity
  • neurodegeneration
  • regional vulnerability

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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