Protein C and S deficiency in children with ischemic cerebrovascular accident

Susan Koh, Lan S. Chen

Research output: Contribution to journalArticle

20 Scopus citations


A prothrombotic state caused by a deficiency of protein C or protein S, each an inhibitor of coagulation cascade, increases the risk of ischemic cerebrovascular accident (ICVA) in young adults. This retrospective review studies the relationship of protein C or S deficiency with childhood ICVA. From 1989 to 1995, 37 children were diagnosed by neuroimaging with ICVA unrelated to any known preexisting diagnosis. Protein C deficiency or protein S deficiency was the only identified risk factor for 5.4% (2 patients) and 13.5% (5 patients), respectively, of these 37 children. The data suggest that protein C or protein S deficiency is an important risk factor of ICVA in children.

Original languageEnglish (US)
Pages (from-to)319-321
Number of pages3
JournalPediatric neurology
Issue number4
StatePublished - Nov 1 1997

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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