Protein disorder is positively correlated with gene expression in escherichia coli

Oleg Paliy, Shawn M. Gargac, Yugong Cheng, Vladimir N. Uversky, A. Dunker

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We considered, on a global scale, the relationship between the predicted fraction of protein disorder and the RNA and protein expression in Escherichia coli. Fraction of protein disorder correlated positively with both measured RNA expression levels of E. coli genes in three different growth media and with predicted abundance levels of E. coli proteins. Though weak, the correlation was highly significant. Correlation of protein disorder with RNA expression did not depend on the growth rate of E. coli cultures and was not caused by a small subset of genes showing exceptionally high concordance in their disorder and expression levels. Global analysis was complemented by detailed consideration of several groups of proteins.

Original languageEnglish (US)
Pages (from-to)2234-2245
Number of pages12
JournalJournal of Proteome Research
Volume7
Issue number6
DOIs
StatePublished - Jun 1 2008

Fingerprint

Gene expression
Escherichia coli
Gene Expression
RNA
Proteins
Genes
Escherichia coli Proteins
Growth

Keywords

  • CAI
  • Disordered proteins
  • Gene expression
  • Microarrays
  • PONDR
  • Protein abundance

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Genetics
  • Biotechnology

Cite this

Protein disorder is positively correlated with gene expression in escherichia coli. / Paliy, Oleg; Gargac, Shawn M.; Cheng, Yugong; Uversky, Vladimir N.; Dunker, A.

In: Journal of Proteome Research, Vol. 7, No. 6, 01.06.2008, p. 2234-2245.

Research output: Contribution to journalArticle

Paliy, Oleg ; Gargac, Shawn M. ; Cheng, Yugong ; Uversky, Vladimir N. ; Dunker, A. / Protein disorder is positively correlated with gene expression in escherichia coli. In: Journal of Proteome Research. 2008 ; Vol. 7, No. 6. pp. 2234-2245.
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