Protein kinase C: Mediator or inhibitor of insulin action?

R. V. Considine, J. F. Caro

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The role of protein kinase C in insulin signal transduction i s controversial It has been postulated that protein kinase C i s activated by insulin and that the kinase i s directly involved in insulin‐mediated metabolic processes. In opposition to this view i s the hypothesis that protein kinase C is not activated by insulin and, more importantly, may be responsible for attenuation of the insulin signal The evidence for and against protein kinase C as a mediator of the insulin signal will be put in perspective followed by discussion of the possible role of the kinase in the pathogenesis of insulin resistance in type II diabetes.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalJournal of Cellular Biochemistry
Issue number1
StatePublished - May 1993


  • PKC
  • diabetes
  • metabolism
  • signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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