Protein kinase C: Mediator or inhibitor of insulin action?

Robert Considine, J. F. Caro

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The role of protein kinase C in insulin signal transduction is controversial. It has been postulated that protein kinase C is activated by insulin and that the kinase is directly involved in insulin-mediated metabolic processes. In opposition to this view is the hypothesis that protein kinase C is not activated by insulin and, more importantly, may be responsible for attenuation of the insulin signal. The evidence for and against protein kinase C as a mediator of the insulin signal will be put in perspective followed by discussion of the possible role of the kinase in the pathogenesis of insulin resistance in type II diabetes.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalJournal of Cellular Biochemistry
Volume52
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Protein C Inhibitor
Protein Kinase Inhibitors
Protein Kinase C
Insulin
Phosphotransferases
Signal transduction
Type 2 Diabetes Mellitus
Medical problems
Insulin Resistance
Signal Transduction

Keywords

  • diabetes
  • metabolism
  • PKC
  • signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Protein kinase C : Mediator or inhibitor of insulin action? / Considine, Robert; Caro, J. F.

In: Journal of Cellular Biochemistry, Vol. 52, No. 1, 1993, p. 8-13.

Research output: Contribution to journalArticle

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