Protein kinase superfamily - comparisons of sequence data with three-dimensional structures

Lei Wei, Stevan R. Hubbard, Randall F. Smith, Leland Ellis

Research output: Contribution to journalArticle

17 Scopus citations


The elucidation of the three-dimensional structures of complexes of the catalytic subunit of mouse recombinant CAMP-dependent protein kinase with bound divalent ion, nucleotide and peptide inhibitor provides new insights into the structural organization of the active site of this enzyme and the probable roles of individual residues in catalysis. Further, the structure of a second member of the eukaryotic kinase superfamily, human cyclin-dependent kinase 2, now provides a first look at both the similarities and the variations in kinase structure.

Original languageEnglish (US)
Pages (from-to)450-455
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number3
StatePublished - Jun 1994


ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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