Protein Phosphatase 1 Binding Proteins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Protein phosphatase 1 belongs to the phosphoprotein phosphatase (PPP) family of phosphatases and is involved in the regulation of a wide variety of cellular processes ranging from intermediary metabolism to apoptosis. It is estimated that almost 300 serine/threonine kinases are encoded by the human genome but only some two-dozen catalytic subunits of serine/threonine protein phosphatases. The question of how such a limited number of protein phosphatases can dephosphorylate the myriad of cellular phosphoproteins in a specific and regulated manner appears to be satisfied by the existence of a multitude of regulatory/targeting subunits. This chapter is limited to mammalian PP1-binding subunits and explains how they can account for the pleiotropic functions of the enzyme in the cell. It also takes into account some other recent reviews on this topic. It suggests that all forms of PP1 holoenzymes contain a similar, highly conserved catalytic subunit but differ in the associated regulatory subunits. The large number of associating proteins provides compelling evidence that the distinctive features of different PP1 holoenzymes reside in the regulatory components. Thus, functionally distinct forms are generated by a combination of a similar catalytic component with different regulatory subunits that are responsible for targeting the enzyme to specific cellular locales, for conferring substrate specificity, or for controlling the enzyme activity. The large number of targeting/ regulatory subunits of PP1 can thus account for the pleiotropic function of the type 1 phosphatase in the cell.

Original languageEnglish
Title of host publicationHandbook of Cell Signaling, 2/e
PublisherElsevier Inc.
Pages689-697
Number of pages9
Volume2
ISBN (Print)9780123741455
DOIs
StatePublished - 2010

Fingerprint

Protein Phosphatase 1
Phosphoprotein Phosphatases
Carrier Proteins
Holoenzymes
Phosphoric Monoester Hydrolases
Catalytic Domain
Enzymes
Protein-Serine-Threonine Kinases
Phosphoproteins
Enzyme activity
Human Genome
Substrate Specificity
Metabolism
Genes
Apoptosis
Substrates
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

De Paoli-Roach, A. (2010). Protein Phosphatase 1 Binding Proteins. In Handbook of Cell Signaling, 2/e (Vol. 2, pp. 689-697). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374145-5.00088-7

Protein Phosphatase 1 Binding Proteins. / De Paoli-Roach, Anna.

Handbook of Cell Signaling, 2/e. Vol. 2 Elsevier Inc., 2010. p. 689-697.

Research output: Chapter in Book/Report/Conference proceedingChapter

De Paoli-Roach, A 2010, Protein Phosphatase 1 Binding Proteins. in Handbook of Cell Signaling, 2/e. vol. 2, Elsevier Inc., pp. 689-697. https://doi.org/10.1016/B978-0-12-374145-5.00088-7
De Paoli-Roach A. Protein Phosphatase 1 Binding Proteins. In Handbook of Cell Signaling, 2/e. Vol. 2. Elsevier Inc. 2010. p. 689-697 https://doi.org/10.1016/B978-0-12-374145-5.00088-7
De Paoli-Roach, Anna. / Protein Phosphatase 1 Binding Proteins. Handbook of Cell Signaling, 2/e. Vol. 2 Elsevier Inc., 2010. pp. 689-697
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