Protein-Specific features associated with variability in human antibody responses to plasmodium falciparum Malaria Antigens

Eugene W. Liu, Jeff Skinner, Tuan M. Tran, Krishan Kumar, David L. Narum, Aarti Jain, Aissata Ongoiba, Boubacar Traore, Philip L. Felgner, Peter D. Crompton

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The magnitude of antibody responses varies across the individual proteins that constitute any given microorganism, both in the context of natural infection and vaccination with attenuated or inactivated pathogens. The protein-specific factors underlying this variability are poorly understood. In 267 individuals exposed to intense seasonal malaria, we examined the relationship between immunoglobulin G (IgG) responses to 861 Plasmodium falciparum proteins and specific features of these proteins, including their subcellular location, relative abundance, degree of polymorphism, and whether they are predicted to have human orthologs. We found that IgG reactivity was significantly higher to extracellular and plasma membrane proteins and also correlated positively with both protein abundance and degree of protein polymorphism. Conversely, IgG reactivity was significantly lower to proteins predicted to have human orthologs. These findings provide insight into protein-specific factors that are associated with variability in the magnitude of antibody responses to natural P. falciparum infection-data that could inform vaccine strategies to optimize antibody-mediated immunity as well as the selection of antigens for sero-diagnostic purposes.

Original languageEnglish (US)
Pages (from-to)57-66
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number1
DOIs
StatePublished - 2018
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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