Protein structure prediction. Introduction to session

A. Dunker, Richard H. Lathrop

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Central Dogma of Molecular Biology is that information flows from DNA sequence to RNA sequence to amino acid sequence which then folds to give protein its correct and 3D structure. One of the most successful approaches is homology modeling. The homology modelled structure is often accurate enough for detailed atomic binding studies and drug discovery programs. However homology modeling is dependent on correct sequence alignments. This paper tries to formulate the protein folding problem as combinatorial optimization. Application of the genetic algorithms to the ab initio prediction of the folded structure is one of the methods. Secondary structure prediction accuracy has risen due to the application of neural networks.

Original languageEnglish (US)
Title of host publicationProceedings of the Hawaii International Conference on System Sciences
EditorsJay F. Nunamaker, Ralph H.Jr. Sprague
PublisherPubl by IEEE
Pages295
Number of pages1
Volume5
ISBN (Print)0818650907
StatePublished - 1995
Externally publishedYes
EventProceedings of the 27th Hawaii International Conference on System Sciences (HICSS-27). Part 4 (of 5) - Wailea, HI, USA
Duration: Jan 4 1994Jan 7 1994

Other

OtherProceedings of the 27th Hawaii International Conference on System Sciences (HICSS-27). Part 4 (of 5)
CityWailea, HI, USA
Period1/4/941/7/94

Fingerprint

Proteins
Protein folding
Molecular biology
DNA sequences
Combinatorial optimization
RNA
Amino acids
Genetic algorithms
Neural networks
Drug Discovery

ASJC Scopus subject areas

  • Software
  • Industrial and Manufacturing Engineering

Cite this

Dunker, A., & Lathrop, R. H. (1995). Protein structure prediction. Introduction to session. In J. F. Nunamaker, & R. H. J. Sprague (Eds.), Proceedings of the Hawaii International Conference on System Sciences (Vol. 5, pp. 295). Publ by IEEE.

Protein structure prediction. Introduction to session. / Dunker, A.; Lathrop, Richard H.

Proceedings of the Hawaii International Conference on System Sciences. ed. / Jay F. Nunamaker; Ralph H.Jr. Sprague. Vol. 5 Publ by IEEE, 1995. p. 295.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dunker, A & Lathrop, RH 1995, Protein structure prediction. Introduction to session. in JF Nunamaker & RHJ Sprague (eds), Proceedings of the Hawaii International Conference on System Sciences. vol. 5, Publ by IEEE, pp. 295, Proceedings of the 27th Hawaii International Conference on System Sciences (HICSS-27). Part 4 (of 5), Wailea, HI, USA, 1/4/94.
Dunker A, Lathrop RH. Protein structure prediction. Introduction to session. In Nunamaker JF, Sprague RHJ, editors, Proceedings of the Hawaii International Conference on System Sciences. Vol. 5. Publ by IEEE. 1995. p. 295
Dunker, A. ; Lathrop, Richard H. / Protein structure prediction. Introduction to session. Proceedings of the Hawaii International Conference on System Sciences. editor / Jay F. Nunamaker ; Ralph H.Jr. Sprague. Vol. 5 Publ by IEEE, 1995. pp. 295
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