Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Xing Jun Li, Charles B G Oodwin, Sarah C. Nabinger, Briana M. Richine, Zhenyun Yang, Helmut Hanenberg, Hiroshi Ohnishi, Takashi Matozaki, Gen Sheng Feng, Rebecca Chan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Innate immune cell oxidative burst is needed to combat pathogens. Results: Loss of Shp2 phosphatase reduces, whereas increased Shp2 phosphatase function enhances, ROS production. Conclusion: The Shp2 phosphatase domain is specifically required for optimal oxidative burst in macrophages. Significance: Humans bearing aberrancies of Shp2 phosphatase or of Shp2-containing signaling pathways may be prone to impaired or excessive ROS production.

Original languageEnglish
Pages (from-to)3894-3909
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

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Protein Tyrosine Phosphatases
Respiratory Burst
Macrophages
Phosphoric Monoester Hydrolases
Bearings (structural)
Pathogens

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., ... Chan, R. (2015). Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. Journal of Biological Chemistry, 290(7), 3894-3909. https://doi.org/10.1074/jbc.M114.614057

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. / Li, Xing Jun; Oodwin, Charles B G; Nabinger, Sarah C.; Richine, Briana M.; Yang, Zhenyun; Hanenberg, Helmut; Ohnishi, Hiroshi; Matozaki, Takashi; Feng, Gen Sheng; Chan, Rebecca.

In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 3894-3909.

Research output: Contribution to journalArticle

Li, XJ, Oodwin, CBG, Nabinger, SC, Richine, BM, Yang, Z, Hanenberg, H, Ohnishi, H, Matozaki, T, Feng, GS & Chan, R 2015, 'Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst', Journal of Biological Chemistry, vol. 290, no. 7, pp. 3894-3909. https://doi.org/10.1074/jbc.M114.614057
Li XJ, Oodwin CBG, Nabinger SC, Richine BM, Yang Z, Hanenberg H et al. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. Journal of Biological Chemistry. 2015 Feb 13;290(7):3894-3909. https://doi.org/10.1074/jbc.M114.614057
Li, Xing Jun ; Oodwin, Charles B G ; Nabinger, Sarah C. ; Richine, Briana M. ; Yang, Zhenyun ; Hanenberg, Helmut ; Ohnishi, Hiroshi ; Matozaki, Takashi ; Feng, Gen Sheng ; Chan, Rebecca. / Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 7. pp. 3894-3909.
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