Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Xing Jun Li, Charles B.G. Oodwin, Sarah C. Nabinger, Briana M. Richine, Zhenyun Yang, Helmut Hanenberg, Hiroshi Ohnishi, Takashi Matozaki, Gen Sheng Feng, Rebecca J. Chan

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Innate immune cell oxidative burst is needed to combat pathogens. Results: Loss of Shp2 phosphatase reduces, whereas increased Shp2 phosphatase function enhances, ROS production. Conclusion: The Shp2 phosphatase domain is specifically required for optimal oxidative burst in macrophages. Significance: Humans bearing aberrancies of Shp2 phosphatase or of Shp2-containing signaling pathways may be prone to impaired or excessive ROS production.

Original languageEnglish (US)
Pages (from-to)3894-3909
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S., & Chan, R. J. (2015). Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. Journal of Biological Chemistry, 290(7), 3894-3909. https://doi.org/10.1074/jbc.M114.614057