Protein tyrosine phosphatases: Prospects for therapeutics

Research output: Contribution to journalReview article

326 Scopus citations

Abstract

Protein tyrosine phosphatases (PTPs) form a large family of enzymes that serve as key regulatory components in signal transduction pathways. Recent gene knockout studies in mice identify PTP1B as a promising target for anti-diabetes/obesity drug discovery. PTPs are also implicated in a wide variety of other disorders, including cancer. Significant progress has been made in identifying small molecules that simultaneously bind both the active site and a unique adjacent site that enables specific inhibition of individual PTP isoenzymes. As a consequence, there are compelling reasons to believe that PTP inhibitors may ultimately serve as powerful therapeutic weapons in our arsenal for battling human diseases.

Original languageEnglish (US)
Pages (from-to)416-423
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume5
Issue number4
DOIs
StatePublished - Aug 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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