Proteinuria, creatinine clearance, and immune activation in antiretroviralNaive HIV-infected subjects

Samir K. Gupta, Lauren Komarow, Roy M. Gulick, Richard B. Pollard, Gregory K. Robbins, Nora Franceschini, Lynda A. Szczech, Susan L. Koletar, Robert C. Kalayjian

20 Scopus citations

Abstract

Because both renal disease and immune activation predict progression to acquired immunodeficiency syndrome (AIDS), we evaluated the associations between proteinuria ≥1+, as determined by dipstick analysis (7 [7%] of 1012 subjects); creatinine clearance of <90 mL/min (195 [18%] of 1071 subjects); and percentages of peripheral activated CD8 cells (CD8 +CD38 +HLA-DR + cells) in antiretroviral-naive, human immunodeficiency virus (HIV)-infected subjects who were enrolled in AIDS Clinical Trials Group studies 384 and A5095. Proteinuria, but not creatinine clearance, was associated with higher percentages of CD8 +CD38 +HLA-DR + cells (55% vs. 50%; P = .01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)614-618
Number of pages5
JournalJournal of Infectious Diseases
Volume200
Issue number4
DOIs
StatePublished - Aug 15 2009

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Gupta, S. K., Komarow, L., Gulick, R. M., Pollard, R. B., Robbins, G. K., Franceschini, N., Szczech, L. A., Koletar, S. L., & Kalayjian, R. C. (2009). Proteinuria, creatinine clearance, and immune activation in antiretroviralNaive HIV-infected subjects. Journal of Infectious Diseases, 200(4), 614-618. https://doi.org/10.1086/600890