Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers

J. Li, Z. Zhuang, H. Okamoto, Alexander Vortmeyer, D. M. Park, M. Furuta, Y. S. Lee, E. H. Oldfield, W. Zeng, R. J. Weil

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Methods to permit more precise delineation of astrocytomas of different grades may have therapeutic utility. The authors selectively microdissected pure populations of cells from normal brain and astrocytomas. They performed two-dimensional protein gel electrophoresis (2DGE) followed by protein sequencing. Differential expression was confirmed immunohistochemically. 2DGE identified proteomic patterns and proteins that differentiated normal brain from tumor and distinguished astrocytomas of increasing grade.

Original languageEnglish (US)
Pages (from-to)733-736
Number of pages4
JournalNeurology
Volume66
Issue number5
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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Astrocytoma
Tumor Biomarkers
Proteomics
Protein Sequence Analysis
Electrophoresis, Gel, Two-Dimensional
Brain Neoplasms
Proteins
Brain
Population
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers. / Li, J.; Zhuang, Z.; Okamoto, H.; Vortmeyer, Alexander; Park, D. M.; Furuta, M.; Lee, Y. S.; Oldfield, E. H.; Zeng, W.; Weil, R. J.

In: Neurology, Vol. 66, No. 5, 01.03.2006, p. 733-736.

Research output: Contribution to journalArticle

Li, J, Zhuang, Z, Okamoto, H, Vortmeyer, A, Park, DM, Furuta, M, Lee, YS, Oldfield, EH, Zeng, W & Weil, RJ 2006, 'Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers', Neurology, vol. 66, no. 5, pp. 733-736. https://doi.org/10.1212/01.wnl.0000201270.90502.d0
Li, J. ; Zhuang, Z. ; Okamoto, H. ; Vortmeyer, Alexander ; Park, D. M. ; Furuta, M. ; Lee, Y. S. ; Oldfield, E. H. ; Zeng, W. ; Weil, R. J. / Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers. In: Neurology. 2006 ; Vol. 66, No. 5. pp. 733-736.
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