Proton MR spectroscopy in patients with seizure disorders

S. N. Breiter, S. Arroyo, Vincent Mathews, R. P. Lesser, R. N. Bryan, P. B. Barker

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To evaluate the ability of proton MR spectroscopy to detect metabolic abnormalities in the seizure focus of humans with epilepsy. METHODS: Single-voxel MR spectroscopy and MR imaging was performed in a group of 13 patients with a variety of seizure disorders and in the temporal lobes of 14 healthy volunteers. Signals from choline, creatine, N-acetyl-L- aspartate, and lactate were quantitated in both the epileptogenic focus and the contralateral brain region. RESULTS: In normal temporal lobe, concentrations of choline, creatine, and N-acetyl-L-aspartate were 2.0 ± 0.7, 7.8 ± 1.9, and 11.0 ± 2.1 μmol/g wet weight, respectively, with no detectable lactate. In all patients, a reduction in the N-acetyl-L-aspartate signal was observed in the electrically defined (scalp electroencephalogram) seizure focus compared with the mirror-image contralateral side. Lactate was elevated only in patients who had seizures during or immediately before the MR examination. Seven of 13 patients studied had normal MR examinations. CONCLUSIONS: Proton spectroscopy demonstrates alterations in N-acetyl-L- aspartate and lactate levels that can be used to locate the epileptogenic focus and may be a useful adjunctive diagnostic technique for the evaluation of patients with seizures who are eligible for resective surgery.

Original languageEnglish (US)
Pages (from-to)373-384
Number of pages12
JournalAmerican Journal of Neuroradiology
Volume15
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Protons
Epilepsy
Magnetic Resonance Spectroscopy
Lactic Acid
Seizures
Creatine
Temporal Lobe
Choline
Scalp
Electroencephalography
Spectrum Analysis
Healthy Volunteers
Weights and Measures
N-acetylaspartate
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Breiter, S. N., Arroyo, S., Mathews, V., Lesser, R. P., Bryan, R. N., & Barker, P. B. (1994). Proton MR spectroscopy in patients with seizure disorders. American Journal of Neuroradiology, 15(2), 373-384.

Proton MR spectroscopy in patients with seizure disorders. / Breiter, S. N.; Arroyo, S.; Mathews, Vincent; Lesser, R. P.; Bryan, R. N.; Barker, P. B.

In: American Journal of Neuroradiology, Vol. 15, No. 2, 1994, p. 373-384.

Research output: Contribution to journalArticle

Breiter, SN, Arroyo, S, Mathews, V, Lesser, RP, Bryan, RN & Barker, PB 1994, 'Proton MR spectroscopy in patients with seizure disorders', American Journal of Neuroradiology, vol. 15, no. 2, pp. 373-384.
Breiter SN, Arroyo S, Mathews V, Lesser RP, Bryan RN, Barker PB. Proton MR spectroscopy in patients with seizure disorders. American Journal of Neuroradiology. 1994;15(2):373-384.
Breiter, S. N. ; Arroyo, S. ; Mathews, Vincent ; Lesser, R. P. ; Bryan, R. N. ; Barker, P. B. / Proton MR spectroscopy in patients with seizure disorders. In: American Journal of Neuroradiology. 1994 ; Vol. 15, No. 2. pp. 373-384.
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