Proton spectroscopy of human brain: Effects of age and sex

H. Cecil Charles, Francois Lazeyras, K. Ranga Rama Krishnan, Orest B. Boyko, Linda J. Patterson, P. Murali Doraiswamy, William M. Mcdonald

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


1. 1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic information from the brains of 34 normal volunteers (15 males) between the ages of 21 and 75 years. 3. 3. Choline, Creatine and N-acetyl aspartate (NAA) was lower in white matter than gray matter. Choline/NAA and choline/creatine ratios were also lower in white matter. The choline, creatine and NAA were lower in older subjects in the voxel representing cortical and subcortical gray matter. There were no differences between males and females. 4. 4. This preliminary study suggests that age matching is essential for comparative studies of disease states using proton MRS.

Original languageEnglish (US)
Pages (from-to)995-1004
Number of pages10
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Issue number6
StatePublished - Oct 1994


  • MRS
  • N-acetyl aspartate
  • choline
  • creatinine

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Proton spectroscopy of human brain: Effects of age and sex'. Together they form a unique fingerprint.

Cite this