Proton spectroscopy of human brain

Effects of age and sex

H. Cecil Charles, Francois Lazeyras, K. Ranga Rama Krishnan, Orest Boyko, Linda J. Patterson, P. Murali Doraiswamy, William M. Mcdonald

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

1. 1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic information from the brains of 34 normal volunteers (15 males) between the ages of 21 and 75 years. 3. 3. Choline, Creatine and N-acetyl aspartate (NAA) was lower in white matter than gray matter. Choline/NAA and choline/creatine ratios were also lower in white matter. The choline, creatine and NAA were lower in older subjects in the voxel representing cortical and subcortical gray matter. There were no differences between males and females. 4. 4. This preliminary study suggests that age matching is essential for comparative studies of disease states using proton MRS.

Original languageEnglish (US)
Pages (from-to)995-1004
Number of pages10
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume18
Issue number6
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Choline
Creatine
Protons
Spectrum Analysis
Brain
Healthy Volunteers
Magnetic Resonance Imaging
N-acetylaspartate
Proton Magnetic Resonance Spectroscopy
White Matter
Gray Matter

Keywords

  • choline
  • creatinine
  • MRS
  • N-acetyl aspartate

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Charles, H. C., Lazeyras, F., Krishnan, K. R. R., Boyko, O., Patterson, L. J., Doraiswamy, P. M., & Mcdonald, W. M. (1994). Proton spectroscopy of human brain: Effects of age and sex. Progress in Neuropsychopharmacology and Biological Psychiatry, 18(6), 995-1004. https://doi.org/10.1016/0278-5846(94)90125-2

Proton spectroscopy of human brain : Effects of age and sex. / Charles, H. Cecil; Lazeyras, Francois; Krishnan, K. Ranga Rama; Boyko, Orest; Patterson, Linda J.; Doraiswamy, P. Murali; Mcdonald, William M.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 18, No. 6, 1994, p. 995-1004.

Research output: Contribution to journalArticle

Charles, HC, Lazeyras, F, Krishnan, KRR, Boyko, O, Patterson, LJ, Doraiswamy, PM & Mcdonald, WM 1994, 'Proton spectroscopy of human brain: Effects of age and sex', Progress in Neuropsychopharmacology and Biological Psychiatry, vol. 18, no. 6, pp. 995-1004. https://doi.org/10.1016/0278-5846(94)90125-2
Charles, H. Cecil ; Lazeyras, Francois ; Krishnan, K. Ranga Rama ; Boyko, Orest ; Patterson, Linda J. ; Doraiswamy, P. Murali ; Mcdonald, William M. / Proton spectroscopy of human brain : Effects of age and sex. In: Progress in Neuropsychopharmacology and Biological Psychiatry. 1994 ; Vol. 18, No. 6. pp. 995-1004.
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