Proximity of prostate cancer to the urethra: Implications for minimally invasive ablative therapies

Bradley C. Leibovich, Michael L. Blute, David G. Bostwick, Torrence M. Wilson, Thomas M. Pisansky, Brian J. Davis, Dharam M. Ramnani, Liang Cheng, Thomas J. Sebo, Horst Zincke

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objectives. The delivery of thermotherapy, cryotherapy, and interstitial radiation with minimal morbidity is dependent on the preservation of the prostatic urethra. Our aim was to determine the distribution of the distance between the urethra and the nearest prostate cancer.Methods. We determined the location of cancer in 350 prostate cancers treated by radical prostatectomy between 1991 and 1993. Each pathologic specimen was totally embedded, serially sectioned, and whole mounted. For each prostate, the radial distance from the urethra to the nearest cancer was determined (urethral-cancer distance). The urethra-cancer distance was correlated with the clinical, pathologic, and laboratory factors. Univariate and multivariate associations with progression-free survival were determined.Results. The mean follow-up was 6.1 years. Ninety-three patients had biochemical, local, or systemic cancer recurrence. The mean ± SD distance from the urethra to the nearest cancer was 3 ± 3 mm (range 0 to 18). In 58 patients (17%), the cancer touched the urethra. A decreasing urethra-cancer distance was associated with increasing rates of cancer recurrence (P = 0.009). The urethra-cancer distance correlated with each of the following preoperative factors: preoperative prostate-specific antigen (r = -0.22, P

Original languageEnglish (US)
Pages (from-to)726-729
Number of pages4
JournalUrology
Volume56
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

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Urethral Neoplasms
Urethra
Prostatic Neoplasms
Neoplasms
Therapeutics
Recurrence
Induced Hyperthermia
Cryotherapy
Prostate-Specific Antigen
Prostatectomy
Disease-Free Survival
Prostate
Radiation
Morbidity

ASJC Scopus subject areas

  • Urology

Cite this

Leibovich, B. C., Blute, M. L., Bostwick, D. G., Wilson, T. M., Pisansky, T. M., Davis, B. J., ... Zincke, H. (2000). Proximity of prostate cancer to the urethra: Implications for minimally invasive ablative therapies. Urology, 56(5), 726-729. https://doi.org/10.1016/S0090-4295(00)00792-5

Proximity of prostate cancer to the urethra : Implications for minimally invasive ablative therapies. / Leibovich, Bradley C.; Blute, Michael L.; Bostwick, David G.; Wilson, Torrence M.; Pisansky, Thomas M.; Davis, Brian J.; Ramnani, Dharam M.; Cheng, Liang; Sebo, Thomas J.; Zincke, Horst.

In: Urology, Vol. 56, No. 5, 2000, p. 726-729.

Research output: Contribution to journalArticle

Leibovich, BC, Blute, ML, Bostwick, DG, Wilson, TM, Pisansky, TM, Davis, BJ, Ramnani, DM, Cheng, L, Sebo, TJ & Zincke, H 2000, 'Proximity of prostate cancer to the urethra: Implications for minimally invasive ablative therapies', Urology, vol. 56, no. 5, pp. 726-729. https://doi.org/10.1016/S0090-4295(00)00792-5
Leibovich BC, Blute ML, Bostwick DG, Wilson TM, Pisansky TM, Davis BJ et al. Proximity of prostate cancer to the urethra: Implications for minimally invasive ablative therapies. Urology. 2000;56(5):726-729. https://doi.org/10.1016/S0090-4295(00)00792-5
Leibovich, Bradley C. ; Blute, Michael L. ; Bostwick, David G. ; Wilson, Torrence M. ; Pisansky, Thomas M. ; Davis, Brian J. ; Ramnani, Dharam M. ; Cheng, Liang ; Sebo, Thomas J. ; Zincke, Horst. / Proximity of prostate cancer to the urethra : Implications for minimally invasive ablative therapies. In: Urology. 2000 ; Vol. 56, No. 5. pp. 726-729.
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AU - Pisansky, Thomas M.

AU - Davis, Brian J.

AU - Ramnani, Dharam M.

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AU - Zincke, Horst

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