Psoriasis and risk of type 2 diabetes among women and men in the United States

A population-based cohort study

Wenqing Li, Jiali Han, Frank B. Hu, Gary C. Curhan, Abrar A. Qureshi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Type 2 diabetes (T2D) shares some common risk factors with psoriasis. We evaluated the association between psoriasis and the risk of incident T2D among women and men in the United States in a mixed retrospective-prospective cohort study. A total of 184,395 participants were included from an older cohort of women (the Nurses Health Study (NHS); 1996-2008), a younger cohort of women (NHS II; 1991-2007), and an older cohort of men (Health Professionals Follow-Up Study (HPFS); 1986-2006). During 2,700,958 person-years of follow-up, 9,938 incident T2D cases were confirmed. We found a significantly increased risk of T2D associated with psoriasis only among younger women (NHS II; multivariate-adjusted relative risk (RR)1.25, 95% confidence interval (CI): 1.05-1.49). When only including those younger than 60 years during follow-up (NHS and HPFS), we observed a nonsignificant trend toward increased risk for T2D. In a pooled analysis of the three cohorts, psoriatics younger than 60 years were at a higher risk of T2D (RR 1.26, 95% CI: 1.08-1.48 for women and RR 1.26, 95% CI: 1.08-1.46 for both sexes combined). In addition, the risk of T2D was much higher for those developing psoriasis at an early age. In conclusion, we found an association between psoriasis and the risk of T2D among individuals younger than 60 years.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalJournal of Investigative Dermatology
Volume132
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

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Medical problems
Psoriasis
Type 2 Diabetes Mellitus
Cohort Studies
Population
Women's Health
Nurses
Confidence Intervals
Health
Men's Health
Prospective Studies

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Psoriasis and risk of type 2 diabetes among women and men in the United States : A population-based cohort study. / Li, Wenqing; Han, Jiali; Hu, Frank B.; Curhan, Gary C.; Qureshi, Abrar A.

In: Journal of Investigative Dermatology, Vol. 132, No. 2, 01.02.2012, p. 291-298.

Research output: Contribution to journalArticle

Li, Wenqing ; Han, Jiali ; Hu, Frank B. ; Curhan, Gary C. ; Qureshi, Abrar A. / Psoriasis and risk of type 2 diabetes among women and men in the United States : A population-based cohort study. In: Journal of Investigative Dermatology. 2012 ; Vol. 132, No. 2. pp. 291-298.
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