Psoriasis, psoriatic arthritis and risk of gout in US men and women

Joseph F. Merola, Shaowei Wu, Jiali Han, Hyon K. Choi, Abrar A. Qureshi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background and objective Individuals with psoriasis have increased blood levels of uric acid. However, there is no prospective data on the association between psoriasis and uric acid levels and subsequent development of gout. In this study, we examined the risk of gout among individuals with psoriasis and psoriatic arthritis (PsA) in two cohorts of men and women, the Health Professionals Follow-up Study (HPFS) (1986-2010) and Nurses Health Study (NHS) (1998-2010). Methods 27 751 men and 71 059 women were included in the analysis. Lifetime history of physiciandiagnosed incident psoriasis and PsA was confirmed by validated supplementary questionnaires. Incident gout diagnoses were confirmed based on the American College of Rheumatology survey criteria. We used Cox proportional hazards models controlling for potential risk factors to calculate the HRs with 95% CIs of incident gout while simultaneously adjusting for several common risk factors. Results We documented 2217 incident cases of gout during follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71 (95% CI 1.36 to 2.15) in the pooled analysis. Risk of gout was substantially augmented among those with psoriasis and concomitant PsA ( pooled multivariate HR: 4.95, 95% CI 2.72 to 9.01) when compared to participants without psoriasis. Conclusions In this prospective study of US women and men, psoriasis and PsA were associated with an increased risk of gout.

Original languageEnglish (US)
Pages (from-to)1495-1500
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume74
Issue number8
DOIs
StatePublished - Aug 1 2015

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Psoriatic Arthritis
Gout
Psoriasis
Uric Acid
Health
Men's Health
Hazards
Women's Health
Blood
Proportional Hazards Models
Nurses
Prospective Studies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Psoriasis, psoriatic arthritis and risk of gout in US men and women. / Merola, Joseph F.; Wu, Shaowei; Han, Jiali; Choi, Hyon K.; Qureshi, Abrar A.

In: Annals of the Rheumatic Diseases, Vol. 74, No. 8, 01.08.2015, p. 1495-1500.

Research output: Contribution to journalArticle

Merola, Joseph F. ; Wu, Shaowei ; Han, Jiali ; Choi, Hyon K. ; Qureshi, Abrar A. / Psoriasis, psoriatic arthritis and risk of gout in US men and women. In: Annals of the Rheumatic Diseases. 2015 ; Vol. 74, No. 8. pp. 1495-1500.
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