Psychiatric and behavioural disorders in children with epilepsy (ILAE Task Force Report): Epilepsy and autism

Frank Besag, Albert Aldenkamp, Rochelle Caplan, David W. Dunn, Giuseppe Gobbi, Matti Sillanpää

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A high proportion of children with epilepsy have autism spectrum disorder. Although estimates vary, depending both on the population studied and the definitions used, a figure of around 20% has typically been reported. Autism can have a major impact on the life of the child and family. Despite the importance of this comorbidity and although many studies have been performed, a full understanding of the possible links between epilepsy and autism remains elusive. In a minority of cases, for example in the Landau-Kleffner syndrome, the autistic features can be the result of the epilepsy itself. However, there has been a failure to demonstrate that the epilepsy itself plays a major role in most cases. The current evidence seems to point to a common underlying predisposing factor. The discovery of a growing number of genetic defects leading to both conditions would support this explanation of the link.

Original languageEnglish (US)
Pages (from-to)S16-S23
JournalEpileptic Disorders
Volume18
StatePublished - May 1 2016

Keywords

  • Autism
  • CSWS
  • ESES
  • Epileptiform
  • Landau-Kleffner

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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