Psychiatric blood biomarkers: Avoiding jumping to premature negative or positive conclusions

A. B. Niculescu, D. Levey, H. Le-Niculescu, E. Niculescu, S. M. Kurian, D. Salomon

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Blood biomarkers may provide a scientifically useful and clinically usable peripheral signal in psychiatry, as they have been doing for other fields of medicine. Jumping to premature conclusions, negative or positive, can create confusion in this field. Reproducibility is a hallmark of good science. We discuss some recent examples from this dynamic field, and show some new data in support of previously published biomarkers for suicidality (SAT1, MARCKS and SKA2). Methodological clarity and rigor in terms of biomarker discovery, validation and testing is needed. We propose a set of principles for what constitutes a good biomarker, similar in spirit to the Koch postulates used at the birth of the field of infectious diseases.

Original languageEnglish (US)
Pages (from-to)286-288
Number of pages3
JournalMolecular Psychiatry
Volume20
Issue number3
DOIs
StatePublished - Mar 12 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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