Psychophysiological evidence of altered neural synchronization in cannabis use

Relationship to schizotypy

Patrick D. Skosnik, Giri P. Krishnan, Erin E. Aydt, Heidi A. Kuhlenshmidt, Brian O'Donnell

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: Cannabis use may produce neurophysiological disturbances similar to those observed in schizophrenia, particularly in relation to altered neural synchronization. Therefore, the current experiment examined the effect of cannabis use on EEG neural synchronization using the auditory steady-state evoked potential. Method: Auditory steady-state evoked potentials were assessed using varying rates of stimulation (auditory click-trains of 20,30, 40 Hz) in current cannabis users (N = 17) and drug-naive comparison subjects (N = 16). EEG spectral power and signal-to-noise ratio at each stimulation frequency were compared between groups. Results: Cannabis users showed decreased EEG power and signal-to-noise ratio at the stimulation frequency of 20 Hz. In addition, current cannabis users demonstrated increased schizotypal personality characteristics as assessed with the Schizotypal Personality Questionnaire, which positively correlated with total years of cannabis use. Finally, within the cannabis group, 20-Hz power values were negatively correlated with Schizotypal Personality Questionnaire scores. Conclusions: These data provide evidence for neural synchronization and early-stage sensory processing deficits in cannabis use. This finding, along with the observed increased rates of schizotypy in cannabis users, adds support for a cannabinoid link to schizophrenia spectrum disorders.

Original languageEnglish
Pages (from-to)1798-1805
Number of pages8
JournalAmerican Journal of Psychiatry
Volume163
Issue number10
DOIs
StatePublished - Oct 2006

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Cannabis
Personality
Electroencephalography
Signal-To-Noise Ratio
Evoked Potentials
Schizophrenia
Acoustic Stimulation
Cannabinoids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Psychophysiological evidence of altered neural synchronization in cannabis use : Relationship to schizotypy. / Skosnik, Patrick D.; Krishnan, Giri P.; Aydt, Erin E.; Kuhlenshmidt, Heidi A.; O'Donnell, Brian.

In: American Journal of Psychiatry, Vol. 163, No. 10, 10.2006, p. 1798-1805.

Research output: Contribution to journalArticle

Skosnik, Patrick D. ; Krishnan, Giri P. ; Aydt, Erin E. ; Kuhlenshmidt, Heidi A. ; O'Donnell, Brian. / Psychophysiological evidence of altered neural synchronization in cannabis use : Relationship to schizotypy. In: American Journal of Psychiatry. 2006 ; Vol. 163, No. 10. pp. 1798-1805.
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