PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Brain and spinal cord injuries initiate widespread temporal and spatial neurodegeneration, through both necrotic and programmed cell death mechanisms. Inflammation, reactive oxidation, excitotoxicity and cell-specific dysregulation of metabolic processes are instigated by traumatic insult and are main contributors to this cumulative damage. Successful treatments rely on prevention or reduction of the magnitude of disruption, and interfering with injurious cellular responses through modulation of signaling cascades is an effective approach. Two intracellular signaling pathways, the phosphatase and tensin homolog (PTEN)/phosphatidylinositol 3-kinase (PI3K) and mitogenactivated protein kinase (MAPK) signaling cascades play various cellular roles under normal and pathological conditions. Activation of both pathways can influence anatomical and functional outcomes in multiple CNS disorders. However, some mechanisms involve inhibiting or enhancing one pathway or the other, or both, in propagating specific downstream effects. Though many intracellular mechanisms contribute to cell responses to insult, this review examines the evidence exploring PTEN/PI3K and MAPK signaling influence on pathology, neuroprotection, and repair and how these pathways may be targeted for advancing knowledge and improving neurological outcome after injury to the brain and spinal cord.

Original languageEnglish
Pages (from-to)421-433
Number of pages13
JournalFrontiers in Biology
Volume8
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Phosphatidylinositol 3-Kinase
phosphatidylinositol 3-kinase
pathology
Phosphoric Monoester Hydrolases
spinal cord
phosphatase
protein kinases
Protein Kinases
Pathology
brain
protein
Wounds and Injuries
Spinal Cord Injuries
Brain Injuries
Spinal Cord
Cell Death
apoptosis
inflammation
cells
oxidation

Keywords

  • axon regeneration
  • MAPK
  • neuroprotection
  • PTEN
  • spinal cord injury
  • traumatic brain injury

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Genetics
  • Ecology

Cite this

PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries. / Walker, Chandler; Liu, Naikui; Xu, Xiao-Ming.

In: Frontiers in Biology, Vol. 8, No. 4, 08.2013, p. 421-433.

Research output: Contribution to journalArticle

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