Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model

Yan Hou, Wanfang Shao, Rong Xiao, Kunlong Xu, Zhizhong Ma, Brian H. Johnstone, Yansheng Du

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Pu-erh tea is believed to possess many beneficial health effects since it is a natural source of cardioprotective lipid lowering and antioxidant compounds, although, the major constituents putatively responsible for these beneficial effects remain unknown. In this study, we examined the effects of two commonly consumed forms of Pu-erh tea, fermented and unfermented, on weight gain, serum levels of lipids and lipoprotein, lipid oxidation, and blood antioxidant enzymes in a rat hyperlipidemia model. Hyperlipidemic rats were treated with water extracts of either 0.5, 1.5 or 3.0 mg/kg fermented or unfermented Pu-erh tea. Serum low density lipoprotein-cholesterol (LDL-C) and triglyceride levels were significantly lowered by tea extract compared to the control group. (p < 0.05) and in most cases were indistinguishable from rats fed normal chow, basal diet. Conversely, levels of high density lipoprotein-cholesterol (HDL-C) were elevated in the groups given daily doses of tea extract (p < 0.05). Compared to the hyperlipidemic control group, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum were significantly elevated in Pu-erh tea-treated groups while levels of malondiadehyde (a byproduct of lipid peroxidation) decreased in the same groups. These effects were most pronounced in the groups treated with the highest dose of fermented Pu-erh tea extract. Our results suggest that Pu-erh tea exerts strong antioxidative and lipid-lowering effects and therefore can be used to reduce the risk of cardiovascular disorders.

Original languageEnglish
Pages (from-to)434-439
Number of pages6
JournalExperimental Gerontology
Volume44
Issue number6-7
DOIs
StatePublished - Jun 2009

Fingerprint

Tea
Hyperlipidemias
Rats
Lipids
Antioxidants
Serum
Control Groups
Nutrition
Glutathione Peroxidase
LDL Cholesterol
HDL Cholesterol
Lipid Peroxidation
Lipoproteins
Superoxide Dismutase
Weight Gain
Byproducts
Blood
Health
Diet
Oxidation

Keywords

  • Hyperlipidemia
  • Lipid peroxidation
  • Obesity
  • Pu-erh tea
  • Serum lipid

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. / Hou, Yan; Shao, Wanfang; Xiao, Rong; Xu, Kunlong; Ma, Zhizhong; Johnstone, Brian H.; Du, Yansheng.

In: Experimental Gerontology, Vol. 44, No. 6-7, 06.2009, p. 434-439.

Research output: Contribution to journalArticle

Hou, Yan ; Shao, Wanfang ; Xiao, Rong ; Xu, Kunlong ; Ma, Zhizhong ; Johnstone, Brian H. ; Du, Yansheng. / Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. In: Experimental Gerontology. 2009 ; Vol. 44, No. 6-7. pp. 434-439.
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