Pulmonary capillaries are recruited during pulsatile flow

Robert Presson, William A. Baumgartner, Amanda J. Peterson, Robb W. Glenny, Wiltz W. Wagner

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Capillaries recruit when pulmonary arterial pressure rises. The duration of increased pressure imposed in such experiments is usually on the order of minutes, although recent work shows that the recruitment response can occur in <4 s. In the present study, we investigate whether the brief pressure rise during cardiac systole can also cause recruitment and whether the recruitment is maintained during diastole. To study these basic aspects of pulmonary capillary hemodynamics, isolated dog lungs were pump perfused alternately by steady flow and pulsatile flow with the mean arterial and left atrial pressures held constant. Several direct measurements of capillary recruitment were made with videomicroscopy. The total number and total length of perfused capillaries increased significantly during pulsatile flow by 94 and 105%, respectively. Of the newly recruited capillaries, 92% were perfused by red blood cells throughout the pulsatile cycle. These data provide the first direct account of how the pulmonary capillaries respond to pulsatile flow by showing that capillaries are recruited during the systolic pulse and that, once open, the capillaries remain open throughout the pulsatile cycle.

Original languageEnglish
Pages (from-to)1183-1190
Number of pages8
JournalJournal of Applied Physiology
Volume92
Issue number3
StatePublished - 2002

Fingerprint

Pulsatile Flow
Lung
Pressure
Video Microscopy
Atrial Pressure
Diastole
Systole
Pulse
Arterial Pressure
Erythrocytes
Hemodynamics
Dogs

Keywords

  • Capillary transit time
  • Dog
  • Microspheres
  • Pulmonary microcirculation
  • Videomicroscopy

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Presson, R., Baumgartner, W. A., Peterson, A. J., Glenny, R. W., & Wagner, W. W. (2002). Pulmonary capillaries are recruited during pulsatile flow. Journal of Applied Physiology, 92(3), 1183-1190.

Pulmonary capillaries are recruited during pulsatile flow. / Presson, Robert; Baumgartner, William A.; Peterson, Amanda J.; Glenny, Robb W.; Wagner, Wiltz W.

In: Journal of Applied Physiology, Vol. 92, No. 3, 2002, p. 1183-1190.

Research output: Contribution to journalArticle

Presson, R, Baumgartner, WA, Peterson, AJ, Glenny, RW & Wagner, WW 2002, 'Pulmonary capillaries are recruited during pulsatile flow', Journal of Applied Physiology, vol. 92, no. 3, pp. 1183-1190.
Presson R, Baumgartner WA, Peterson AJ, Glenny RW, Wagner WW. Pulmonary capillaries are recruited during pulsatile flow. Journal of Applied Physiology. 2002;92(3):1183-1190.
Presson, Robert ; Baumgartner, William A. ; Peterson, Amanda J. ; Glenny, Robb W. ; Wagner, Wiltz W. / Pulmonary capillaries are recruited during pulsatile flow. In: Journal of Applied Physiology. 2002 ; Vol. 92, No. 3. pp. 1183-1190.
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