Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks

Amy C. Short, Michael L. Montoya, Sarah A. Gebb, Robert Presson, Wiltz W. Wagner, Ronald L. Capen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In vivo microscopic observations of pulmonary capillaries are limited to subpleural networks that are less dense than interior networks. In addition to the density difference, subpleural and interior capillary diameters may differ, although there are conflicting data on this point. We measured the diameters of subpleural and interior capillaries in rats and dogs. Subpleural diameters were 30% larger in rats and 20% larger in dogs. Because diameter and density differences might cause differences in recruitment between subpleural and interior networks, we measured subpleural and interior recruitment by counting the number of red blood cells per 10 μm of alveolar wall in histological cross sections of rapidly frozen rat lungs. Lung inflation pressures of 4, 12, and 25 cmH2O created a wide range of capillary recruitment in different groups of animals. Red blood cell counts for interior and subpleural capillaries moved in parallel and progressively increased as inflation pressures were reduced. These data demonstrate that recruitment in subpleural capillaries accurately reflect recruitment in interior capillaries and validate the use of in vivo microscopic observations of subpleural capillaries to investigate pulmonary capillary recruitment in general.

Original languageEnglish (US)
Pages (from-to)1568-1573
Number of pages6
JournalJournal of Applied Physiology
Volume80
Issue number5
StatePublished - May 1996
Externally publishedYes

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Lung
Economic Inflation
Dogs
Pressure
Erythrocyte Count
Frozen Sections
Erythrocytes

Keywords

  • dogs
  • rats

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Short, A. C., Montoya, M. L., Gebb, S. A., Presson, R., Wagner, W. W., & Capen, R. L. (1996). Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks. Journal of Applied Physiology, 80(5), 1568-1573.

Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks. / Short, Amy C.; Montoya, Michael L.; Gebb, Sarah A.; Presson, Robert; Wagner, Wiltz W.; Capen, Ronald L.

In: Journal of Applied Physiology, Vol. 80, No. 5, 05.1996, p. 1568-1573.

Research output: Contribution to journalArticle

Short, AC, Montoya, ML, Gebb, SA, Presson, R, Wagner, WW & Capen, RL 1996, 'Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks', Journal of Applied Physiology, vol. 80, no. 5, pp. 1568-1573.
Short, Amy C. ; Montoya, Michael L. ; Gebb, Sarah A. ; Presson, Robert ; Wagner, Wiltz W. ; Capen, Ronald L. / Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks. In: Journal of Applied Physiology. 1996 ; Vol. 80, No. 5. pp. 1568-1573.
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