Pulmonary Function in Bronchopulmonary Dysplasia

Beverley Robin, Young Jee Kim, Jaimee Huth, Jim Klocksieben, Margaret Torres, Robert Tepper, Robert G. Castile, Julian Solway, Marc B. Hershenson, Amy Goldstein-Filbrun

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The purpose of this study was to examine lung function and bronchodilator responsiveness in infants with a history of prematurity and bronchopulmonary dysplasia (BPD), using the raised volume rapid thoracoabdominal compression technique as well as with whole-body plethysmography. Spirometric measurements were obtained in 28 infants with a history of BPD, defined as preterm birth with O2 requirement at 36 weeks postmenstrual age (gestational age at birth, 26.4 ± 2.1 weeks, mean ± SD; birthweight, 898 ± 353 g; age at study, 68.0 ± 35.6 weeks). Fractional lung volumes were measured in 27 subjects. Values were expressed as percentage of predicted normal values. Compared to normal infants, those with a history of BPD exhibited decreases in forced expiratory flows including forced expiratory volume in 0.5 sec (76.3 ± 19.6%), forced expiratory flow at 75% of expired forced vital capacity (FEF75; 59.5 ± 30.7%), and FEF25-75 (74.0 ± 26.8%; P < 0.01 for all). Functional residual capacity (107.9 ± 25.3%), residual volume (RV, 124.5 ± 42.7%), and RV/total lung capacity (RV/TLC, 128.2 ± 35.3%) were increased in infants with a history of BPD (P < 0.05 for each). There was no difference in TLC between groups. Seventeen infants were studied both pre- and postalbuterol, and 6 (35%) demonstrated significant bronchodilator responsiveness. Infants with recurrent wheezing showed greater expiratory flow limitation, hyperinflation, and airways responsiveness, whereas those without wheezing showed only modest airway dysfunction. We conclude that infants with a history of BPD have pulmonary function abnormalities characterized by mild to moderate airflow obstruction and air trapping.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalPediatric Pulmonology
Volume37
Issue number3
DOIs
StatePublished - Mar 2004

Fingerprint

Bronchopulmonary Dysplasia
Lung
Bronchodilator Agents
Respiratory Sounds
Whole Body Plethysmography
Total Lung Capacity
Functional Residual Capacity
Residual Volume
Vital Capacity
Premature Birth
Forced Expiratory Volume
Gestational Age
Reference Values
Air
Parturition

Keywords

  • Airflow obstruction
  • Bronchodilator responsiveness
  • Hyperinflation
  • Infants
  • Plethysmography
  • Prematurity
  • Raised volume-rapid thoracoabdominal compression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Robin, B., Kim, Y. J., Huth, J., Klocksieben, J., Torres, M., Tepper, R., ... Goldstein-Filbrun, A. (2004). Pulmonary Function in Bronchopulmonary Dysplasia. Pediatric Pulmonology, 37(3), 236-242. https://doi.org/10.1002/ppul.10424

Pulmonary Function in Bronchopulmonary Dysplasia. / Robin, Beverley; Kim, Young Jee; Huth, Jaimee; Klocksieben, Jim; Torres, Margaret; Tepper, Robert; Castile, Robert G.; Solway, Julian; Hershenson, Marc B.; Goldstein-Filbrun, Amy.

In: Pediatric Pulmonology, Vol. 37, No. 3, 03.2004, p. 236-242.

Research output: Contribution to journalArticle

Robin, B, Kim, YJ, Huth, J, Klocksieben, J, Torres, M, Tepper, R, Castile, RG, Solway, J, Hershenson, MB & Goldstein-Filbrun, A 2004, 'Pulmonary Function in Bronchopulmonary Dysplasia', Pediatric Pulmonology, vol. 37, no. 3, pp. 236-242. https://doi.org/10.1002/ppul.10424
Robin B, Kim YJ, Huth J, Klocksieben J, Torres M, Tepper R et al. Pulmonary Function in Bronchopulmonary Dysplasia. Pediatric Pulmonology. 2004 Mar;37(3):236-242. https://doi.org/10.1002/ppul.10424
Robin, Beverley ; Kim, Young Jee ; Huth, Jaimee ; Klocksieben, Jim ; Torres, Margaret ; Tepper, Robert ; Castile, Robert G. ; Solway, Julian ; Hershenson, Marc B. ; Goldstein-Filbrun, Amy. / Pulmonary Function in Bronchopulmonary Dysplasia. In: Pediatric Pulmonology. 2004 ; Vol. 37, No. 3. pp. 236-242.
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