Pulmonary hilar stereotactic body radiation therapy in the rat

B. Tinnel, Marc Mendonca, M. Henderson, Oscar Cummings, H. Chin-Sinex, R. Timmerman, R. C. McGarry

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Stereotactic Body Radiation therapy (SBRT) is an emerging modality of treatment for early stage non-small cell lung carcinoma. Concerns have arisen related to increased toxicities for medial tumors. We have developed a model of high dose, hypofractionated radiotherapy to the pulmonary hilum using the Leksell Gamma-Knife™. Sprague-Dawley rats received hypofractionated SBRT to the unilateral lung hilum using a custom immobilization device on the Gamma Knife. Each animal was individually scanned, treatment planned, and treated with either two 4 mm or one 8 mm collimated shots at escalating doses of 20, 40, and 80 Gy to the 50% isodose volume, encompassing the right mainstem bronchus. All animals were carefully followed post-treatment and imaged by plain film and CT. In addition, histopathological analysis of all rats was performed at selected time points. Animals treated with 4 mm collimated shots demonstrated no appreciable changes on plain films or sequential, follow-up CT scans, or histopathologically. Animals irradiated with the 8 mm collimator were less active, gained weight at a reduced rate, and demonstrated histopathological changes in 7/34 animals six months post-irradiation. Cellular atypia and interstitial pneumonitis were found, three of the seven of the animals showed clear bronchial damage and two showed vascular damage. Significant volume and time effects were found. Utilizing a novel Gamma Knife based animal model to study SBRT toxicity, it was found that the bronchus will tolerate small volumes of very high dose radiotherapy. It was postulated that radiation of the surrounding support stroma and normal tissue are important in the etiology of bronchial or hilar damage.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalTechnology in Cancer Research and Treatment
Volume6
Issue number5
StatePublished - Oct 2007

Fingerprint

Radiotherapy
Lung
Bronchi
Motion Pictures
Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Immobilization
Blood Vessels
Sprague Dawley Rats
Therapeutics
Animal Models
Radiation
Weights and Measures
Equipment and Supplies
Neoplasms

Keywords

  • Animal model
  • Gamma knife
  • Lung cancer
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Tinnel, B., Mendonca, M., Henderson, M., Cummings, O., Chin-Sinex, H., Timmerman, R., & McGarry, R. C. (2007). Pulmonary hilar stereotactic body radiation therapy in the rat. Technology in Cancer Research and Treatment, 6(5), 425-431.

Pulmonary hilar stereotactic body radiation therapy in the rat. / Tinnel, B.; Mendonca, Marc; Henderson, M.; Cummings, Oscar; Chin-Sinex, H.; Timmerman, R.; McGarry, R. C.

In: Technology in Cancer Research and Treatment, Vol. 6, No. 5, 10.2007, p. 425-431.

Research output: Contribution to journalArticle

Tinnel, B, Mendonca, M, Henderson, M, Cummings, O, Chin-Sinex, H, Timmerman, R & McGarry, RC 2007, 'Pulmonary hilar stereotactic body radiation therapy in the rat', Technology in Cancer Research and Treatment, vol. 6, no. 5, pp. 425-431.
Tinnel, B. ; Mendonca, Marc ; Henderson, M. ; Cummings, Oscar ; Chin-Sinex, H. ; Timmerman, R. ; McGarry, R. C. / Pulmonary hilar stereotactic body radiation therapy in the rat. In: Technology in Cancer Research and Treatment. 2007 ; Vol. 6, No. 5. pp. 425-431.
@article{09da5dcbfa22414e88f102e76e173fd4,
title = "Pulmonary hilar stereotactic body radiation therapy in the rat",
abstract = "Stereotactic Body Radiation therapy (SBRT) is an emerging modality of treatment for early stage non-small cell lung carcinoma. Concerns have arisen related to increased toxicities for medial tumors. We have developed a model of high dose, hypofractionated radiotherapy to the pulmonary hilum using the Leksell Gamma-Knife™. Sprague-Dawley rats received hypofractionated SBRT to the unilateral lung hilum using a custom immobilization device on the Gamma Knife. Each animal was individually scanned, treatment planned, and treated with either two 4 mm or one 8 mm collimated shots at escalating doses of 20, 40, and 80 Gy to the 50{\%} isodose volume, encompassing the right mainstem bronchus. All animals were carefully followed post-treatment and imaged by plain film and CT. In addition, histopathological analysis of all rats was performed at selected time points. Animals treated with 4 mm collimated shots demonstrated no appreciable changes on plain films or sequential, follow-up CT scans, or histopathologically. Animals irradiated with the 8 mm collimator were less active, gained weight at a reduced rate, and demonstrated histopathological changes in 7/34 animals six months post-irradiation. Cellular atypia and interstitial pneumonitis were found, three of the seven of the animals showed clear bronchial damage and two showed vascular damage. Significant volume and time effects were found. Utilizing a novel Gamma Knife based animal model to study SBRT toxicity, it was found that the bronchus will tolerate small volumes of very high dose radiotherapy. It was postulated that radiation of the surrounding support stroma and normal tissue are important in the etiology of bronchial or hilar damage.",
keywords = "Animal model, Gamma knife, Lung cancer, Stereotactic body radiation therapy",
author = "B. Tinnel and Marc Mendonca and M. Henderson and Oscar Cummings and H. Chin-Sinex and R. Timmerman and McGarry, {R. C.}",
year = "2007",
month = "10",
language = "English",
volume = "6",
pages = "425--431",
journal = "Technology in Cancer Research and Treatment",
issn = "1533-0346",
publisher = "Adenine Press",
number = "5",

}

TY - JOUR

T1 - Pulmonary hilar stereotactic body radiation therapy in the rat

AU - Tinnel, B.

AU - Mendonca, Marc

AU - Henderson, M.

AU - Cummings, Oscar

AU - Chin-Sinex, H.

AU - Timmerman, R.

AU - McGarry, R. C.

PY - 2007/10

Y1 - 2007/10

N2 - Stereotactic Body Radiation therapy (SBRT) is an emerging modality of treatment for early stage non-small cell lung carcinoma. Concerns have arisen related to increased toxicities for medial tumors. We have developed a model of high dose, hypofractionated radiotherapy to the pulmonary hilum using the Leksell Gamma-Knife™. Sprague-Dawley rats received hypofractionated SBRT to the unilateral lung hilum using a custom immobilization device on the Gamma Knife. Each animal was individually scanned, treatment planned, and treated with either two 4 mm or one 8 mm collimated shots at escalating doses of 20, 40, and 80 Gy to the 50% isodose volume, encompassing the right mainstem bronchus. All animals were carefully followed post-treatment and imaged by plain film and CT. In addition, histopathological analysis of all rats was performed at selected time points. Animals treated with 4 mm collimated shots demonstrated no appreciable changes on plain films or sequential, follow-up CT scans, or histopathologically. Animals irradiated with the 8 mm collimator were less active, gained weight at a reduced rate, and demonstrated histopathological changes in 7/34 animals six months post-irradiation. Cellular atypia and interstitial pneumonitis were found, three of the seven of the animals showed clear bronchial damage and two showed vascular damage. Significant volume and time effects were found. Utilizing a novel Gamma Knife based animal model to study SBRT toxicity, it was found that the bronchus will tolerate small volumes of very high dose radiotherapy. It was postulated that radiation of the surrounding support stroma and normal tissue are important in the etiology of bronchial or hilar damage.

AB - Stereotactic Body Radiation therapy (SBRT) is an emerging modality of treatment for early stage non-small cell lung carcinoma. Concerns have arisen related to increased toxicities for medial tumors. We have developed a model of high dose, hypofractionated radiotherapy to the pulmonary hilum using the Leksell Gamma-Knife™. Sprague-Dawley rats received hypofractionated SBRT to the unilateral lung hilum using a custom immobilization device on the Gamma Knife. Each animal was individually scanned, treatment planned, and treated with either two 4 mm or one 8 mm collimated shots at escalating doses of 20, 40, and 80 Gy to the 50% isodose volume, encompassing the right mainstem bronchus. All animals were carefully followed post-treatment and imaged by plain film and CT. In addition, histopathological analysis of all rats was performed at selected time points. Animals treated with 4 mm collimated shots demonstrated no appreciable changes on plain films or sequential, follow-up CT scans, or histopathologically. Animals irradiated with the 8 mm collimator were less active, gained weight at a reduced rate, and demonstrated histopathological changes in 7/34 animals six months post-irradiation. Cellular atypia and interstitial pneumonitis were found, three of the seven of the animals showed clear bronchial damage and two showed vascular damage. Significant volume and time effects were found. Utilizing a novel Gamma Knife based animal model to study SBRT toxicity, it was found that the bronchus will tolerate small volumes of very high dose radiotherapy. It was postulated that radiation of the surrounding support stroma and normal tissue are important in the etiology of bronchial or hilar damage.

KW - Animal model

KW - Gamma knife

KW - Lung cancer

KW - Stereotactic body radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=35348980736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348980736&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 425

EP - 431

JO - Technology in Cancer Research and Treatment

JF - Technology in Cancer Research and Treatment

SN - 1533-0346

IS - 5

ER -