Pulmonary hypertension associated with chronic hemolytic anemia and other blood disorders

Roberto F. Machado, Harrison W. Farber

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Pulmonary hypertension (PH) has emerged as a major complication of several hematologic disorders, including hemoglobinopathies, red cell membrane disorders, chronic myeloproliferative disorders, and splenectomy. With the exception of sickle cell disease, there are a limited number of studies systematically evaluating the prevalence of PH using the gold standard right heart catheterization in these disorders. The cause of the PH in patients with hematologic disorders is multifactorial, and a thorough diagnostic evaluation is essential. More importantly, there are virtually no high-quality data on the safety and efficacy of PH-targeted therapy in this patient population.

Original languageEnglish (US)
Pages (from-to)739-752
Number of pages14
JournalClinics in Chest Medicine
Volume34
Issue number4
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Keywords

  • Myeloproliferative disorders
  • Pulmonary hypertension
  • Sickle cell disease
  • Splenectomy
  • Thalassemia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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