Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults

Stephen B. Gordon, David E. Miller, Richard B. Day, Tom Ferry, David S. Wilkes, Carol T. Schnizlein-Bick, Eduard E. Zijlstra, Robert C. Read, Malcolm E. Molyneux, Homer L. Twigg

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P = .001).

Original languageEnglish (US)
Pages (from-to)666-670
Number of pages5
JournalJournal of Infectious Diseases
Volume188
Issue number5
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults'. Together they form a unique fingerprint.

  • Cite this

    Gordon, S. B., Miller, D. E., Day, R. B., Ferry, T., Wilkes, D. S., Schnizlein-Bick, C. T., Zijlstra, E. E., Read, R. C., Molyneux, M. E., & Twigg, H. L. (2003). Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. Journal of Infectious Diseases, 188(5), 666-670. https://doi.org/10.1086/377480