Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults

Stephen B. Gordon, David E. Miller, Richard B. Day, Tom Ferry, David S. Wilkes, Carol T. Schnizlein-Bick, Eduard E. Zijlstra, Robert C. Read, Malcolm E. Molyneux, Homer Twigg

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P = .001).

Original languageEnglish
Pages (from-to)666-670
Number of pages5
JournalJournal of Infectious Diseases
Volume188
Issue number5
DOIs
StatePublished - Sep 1 2003

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Streptococcus pneumoniae
Immunoglobulins
HIV
Lung
Bronchoalveolar Lavage
Immunoglobulin G
Immunoglobulin M
Pneumococcal Infections
Respiratory System
Polysaccharides
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. / Gordon, Stephen B.; Miller, David E.; Day, Richard B.; Ferry, Tom; Wilkes, David S.; Schnizlein-Bick, Carol T.; Zijlstra, Eduard E.; Read, Robert C.; Molyneux, Malcolm E.; Twigg, Homer.

In: Journal of Infectious Diseases, Vol. 188, No. 5, 01.09.2003, p. 666-670.

Research output: Contribution to journalArticle

Gordon, SB, Miller, DE, Day, RB, Ferry, T, Wilkes, DS, Schnizlein-Bick, CT, Zijlstra, EE, Read, RC, Molyneux, ME & Twigg, H 2003, 'Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults', Journal of Infectious Diseases, vol. 188, no. 5, pp. 666-670. https://doi.org/10.1086/377480
Gordon, Stephen B. ; Miller, David E. ; Day, Richard B. ; Ferry, Tom ; Wilkes, David S. ; Schnizlein-Bick, Carol T. ; Zijlstra, Eduard E. ; Read, Robert C. ; Molyneux, Malcolm E. ; Twigg, Homer. / Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. In: Journal of Infectious Diseases. 2003 ; Vol. 188, No. 5. pp. 666-670.
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