Pulsed laser radiation effects on the distribution of conduction velocities in sciatic nerve of the rat

Shien Fong Lin, Ursula Wesselmann, William Z. Rymer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The effects of subablative Q-switched Nd-YAG laser irradiation on the nerve fiber population of the sciatic nerve in rat were estimated using a quantitative method. The acute and cumulative effects were evaluated separately. When 5-minute laser irradiation was applied to the sciatic nerve, there was a differential decrease in the number of active fibers in slow and fast fiber classes. Fast fibers were insensitive to the radiation as the number of fibers was not altered significantly except at high radiating energies. The amount of decrease in each fiber class was not strictly proportional to the radiating laser energy. The cumulative effects show an exponential decay in fiber number after radiation sequence of gradually incremented laser pulse energy. Similarly, the impairment of fast fiber classes was less significant than slow fiber classes. At high cumulative optical energy, the number of fibers in fast fiber classes started decreasing whereas fiber population in slow fiber classes increased. We postulate that the impairment of the node of Ranvier was the dominant mechanism at low energy radiation, whereas the change in the cable properties of internodes resulted in the shift of fast fibers to slower fiber classes.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsStephen N. Joffe, Kazuhiko Atsumi
PublisherPubl by Int Soc for Optical Engineering
Pages334-342
Number of pages9
ISBN (Print)0819402419
StatePublished - Dec 1 1990
Externally publishedYes
EventProceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II - Los Angeles, CA, USA
Duration: Jan 14 1990Jan 19 1990

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1200
ISSN (Print)0277-786X

Other

OtherProceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II
CityLos Angeles, CA, USA
Period1/14/901/19/90

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Lin, S. F., Wesselmann, U., & Rymer, W. Z. (1990). Pulsed laser radiation effects on the distribution of conduction velocities in sciatic nerve of the rat. In S. N. Joffe, & K. Atsumi (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 334-342). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1200). Publ by Int Soc for Optical Engineering.