Purification of carbon-11 pet radiotracers from unlabeled precursors by preparative HPLC and SPE

Qi Huang Zheng, Bruce H. Mock

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [11C]radopride, [11C]β-CFT and [11C]choline from their unlabeled precursors.

Original languageEnglish (US)
Pages (from-to)671-676
Number of pages6
JournalBiomedical Chromatography
Volume19
Issue number9
DOIs
StatePublished - Nov 1 2005

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Keywords

  • Carbon-11 radiotracer
  • HPLC
  • Positron emission tomography
  • SPE

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

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