3′-C-Methyladenosine (3′-Me-Ado) is a mechanism-based ribonucleotide reductase inhibitor endowed with antitumor activity against both human leukemia and carcinoma cell lines. In this paper, we report the synthesis and antitumor evaluation of a series of purine and pyrimidine 3′-C-methylribonucleoside analogs of 3′-Me-Ado. A stereoselective synthesis of the arabino analog of 3′-Me-Ado is also described. Among the tested compounds, only 3′-C-methyluridine showed moderate antitumor activity against human myelogenous leukemia K562 cell line.
|Original language||English (US)|
|Number of pages||11|
|Journal||Collection of Czechoslovak Chemical Communications|
|State||Published - Jul 1 2006|
- C-Branched nucleosides
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