Purkinje cell loss and the noradrenergic system in the cerebellum of pcd mutant mice

Bernardino Ghetti, Ray W. Fuller, Barry D. Sawyer, Susan K. Hemrick-Luecke, Michael J. Schmidt

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Purkinje cells in the cerebellum receive inhibitory noradrenergic input from the locus coeruleus. In pcd mutant mice all Purkinje cells degenerate by 45 days of age. The purpose of the present studies was to determine if the loss of these cerebellar neurons affects the amounts of norepinephrine in the cerebellum of mice 25-280 days of age. No significant changes in norepinephrine content were detected during or after Purkinje cell degeneration. However, since degeneration led to a reduction in cerebellar weight, the norepinephrine concentration was increased in pcd mutants. These results indicate that despite the loss of a major postsynaptic target (Purkinje cells), the cerebellar noradrenergic input remains stable.

Original languageEnglish (US)
Pages (from-to)711-714
Number of pages4
JournalBrain Research Bulletin
Volume7
Issue number6
DOIs
StatePublished - Dec 1981

    Fingerprint

Keywords

  • Cerebellum
  • Degeneration
  • Mutant
  • Norepinephrine
  • Purkinje cell pcd

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this