Putting the actin cytoskeleton into perspective: pathophysiology of ischémie alterations

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Abstract

The actin cvtoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of ischémie cell injury. Rho guanosinetriphosphatases; actin-binding proteins; actin regulation

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume41
Issue number4
StatePublished - 1997

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Actin Cytoskeleton
Actins
Microfilament Proteins
Cell Polarity
Proteins
GTP Phosphohydrolases
Exocytosis
Cellular Structures
Endocytosis
Ion Channels
Cell Adhesion
Cell Division
Signal Transduction
Membranes
Wounds and Injuries

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "Putting the actin cytoskeleton into perspective: pathophysiology of isch{\'e}mie alterations",
abstract = "The actin cvtoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of isch{\'e}mie cell injury. Rho guanosinetriphosphatases; actin-binding proteins; actin regulation",
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