Putting the actin cytoskeleton into perspective: Pathophysiology of ischemic alterations

Research output: Contribution to journalReview article

73 Scopus citations

Abstract

The actin cvtoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of ischémie cell injury. Rho guanosinetriphosphatases; actin-binding proteins; actin regulation

Original languageEnglish (US)
Pages (from-to)F430-F433
JournalAmerican Journal of Physiology - Renal Physiology
Volume272
Issue number4 41-4
StatePublished - Apr 1 1997

    Fingerprint

Keywords

  • Actin regulation
  • Actin-binding proteins
  • Rho guanosinetriphosphatases

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this