Putting the actin cytoskeleton into perspective: Pathophysiology of ischemie alterations

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The actin cytoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of ischemic cell injury.

Original languageEnglish
JournalThe American journal of physiology
Volume272
Issue number4 PART 2
StatePublished - 1997

Fingerprint

Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
Cellular Structures
Endocytosis
Ion Channels
Cell Adhesion
Cell Division
Signal Transduction
Membranes
Wounds and Injuries

Keywords

  • Actin regulation
  • Actin-binding proteins
  • Rho guanosinetriphosphatases

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

@article{f06eb03f8ac94179a0fc2156a5bf7323,
title = "Putting the actin cytoskeleton into perspective: Pathophysiology of ischemie alterations",
abstract = "The actin cytoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of ischemic cell injury.",
keywords = "Actin regulation, Actin-binding proteins, Rho guanosinetriphosphatases",
author = "Bruce Molitoris",
year = "1997",
language = "English",
volume = "272",
journal = "American Journal of Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "4 PART 2",

}

TY - JOUR

T1 - Putting the actin cytoskeleton into perspective

T2 - Pathophysiology of ischemie alterations

AU - Molitoris, Bruce

PY - 1997

Y1 - 1997

N2 - The actin cytoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of ischemic cell injury.

AB - The actin cytoskeleton plays an ever-increasingly understood role in mediating a myriad of processes necessary for cellular structure and function. New and exciting information regarding the dynamic aspects of the actin cytoskeleton and its intracellular regulation are unfolding at a rapid rate. Actin cytoskeletal-surface membrane interactions mediating such diverse cellular events as cell polarity, endocytosis, exocytosis, cell division, cellular migration, cell adhesion, signal transduction, and ion channel activity are part of an ever-growing list of cellular processes dependent on precise actin polarization and regulation of assembly and disassembly. The purpose of this review is to highlight recent advances in the understanding of actin cytoskeleton-mediated cellular processes, to provide a framework that interrelates the complex protein-protein interactions necessary for localization, regulation, and mediation of these essential cellular functions, and to outline the role of actin effector proteins in the pathophysiology of ischemic cell injury.

KW - Actin regulation

KW - Actin-binding proteins

KW - Rho guanosinetriphosphatases

UR - http://www.scopus.com/inward/record.url?scp=33745345159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745345159&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33745345159

VL - 272

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0193-1857

IS - 4 PART 2

ER -