Quality of life in adults with nonalcoholic fatty liver disease

Baseline data from the nonalcoholic steatohepatitis clinical research network

Kristin David, Kris V. Kowdley, Aynur Unalp, Fasiha Kanwal, Elizabeth M. Brunt, Jeffrey B. Schwimmer, Stephanie Abrams, Diana Arceo, Denise Espinosa, Leanel Fairly, Arthur McCullough, Diane Bringman, Srinivasan Dasarathy, Carol Hawkins, Yao Chang Liu, Nicholette Rogers, Margaret Stager, Kevin Edwards, Ruth Sargent, Melissa Coffey & 95 others Karen Murray, Melissa Young, Parvathi Mohan, Kavita Nair, Anna Mae Diehl, Marcia Gortfried, Cynthia Guy, Paul Killenberg, Samantha Kwan, Yi Ping Pan, Dawn Piercy, Melissa Smith, Prajakta Bhimalli, Naga Chalasani, Oscar Cummings, Lydia Lee, Linda Ragozzino, Raj Vuppalanchi, Ann Scheimann, Michael Torbenson, Ann Klipsch, Jean Molleston, Girish Subbarao, Sarah Barlow, Jose Derdoy, Joyce Hoffmann, Debra King, Joan Siegner, Susan Stewart, Brent A. Tetri, Judy Thompson, Cynthia Behling, Manual Celedon, Lisa Clark, Janis Durelle, Tarek Hassanein, Joel E. Lavine, Susana Mendoza, Claude Sirlin, Tanya Stein, Allison Tobin, Kiran Bambha, Nathan M. Bass, Linda D. Ferrell, Danuta Filipowski, Raphael Merriman, Mark Pabst, Monique Rosenthal, Philip Rosenthal, Tessa Steel, Sherry Boyett, Daphne Bryan, Melissa J. Contos, Michael Fuchs, Martin Graham, Amy Jones, Velimir A C Luketic, Bimalijit Sandhu, Arun J. Sanyal, Carol Sargeant, Kimberly Selph, Melanie White, Grace Gyurkey, Jody Mooney, James Nelson, Sarah Roberts, Cheryl Saunders, Alice Stead, Chia Wang, Matthew Yeh, Elizabeth Brunt, David Kleiner, Gilman D. Grave, Terry T K Huang, Edward Doo, James E. Everhart, Jay H. Hoofnagle, Patricia R. Robuck, Leonard Seeff, Patricia Belt, Fred Brancati, Jeanne Clark, Ryan Colvin, Michele Donithan, Mika Green, Rosemary Hollick, Milana Isaacson, Wana Kim, Alison Lydecker, Laura Miriel, Alice Sternberg, James Tonascia, Mark Van Natta, Laura Wilson, Katherine Yates

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.

Original languageEnglish
Pages (from-to)1904-1912
Number of pages9
JournalHepatology
Volume49
Issue number6
DOIs
StatePublished - Jun 2009

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Quality of Life
Research
Fibrosis
Health
Non-alcoholic Fatty Liver Disease
Liver Diseases
Mental Health
Chronic Disease
Cost of Illness
Fatty Liver
Population
Histology
Pathology
Biopsy
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

David, K., Kowdley, K. V., Unalp, A., Kanwal, F., Brunt, E. M., Schwimmer, J. B., ... Yates, K. (2009). Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network. Hepatology, 49(6), 1904-1912. https://doi.org/10.1002/hep.22868

Quality of life in adults with nonalcoholic fatty liver disease : Baseline data from the nonalcoholic steatohepatitis clinical research network. / David, Kristin; Kowdley, Kris V.; Unalp, Aynur; Kanwal, Fasiha; Brunt, Elizabeth M.; Schwimmer, Jeffrey B.; Abrams, Stephanie; Arceo, Diana; Espinosa, Denise; Fairly, Leanel; McCullough, Arthur; Bringman, Diane; Dasarathy, Srinivasan; Hawkins, Carol; Liu, Yao Chang; Rogers, Nicholette; Stager, Margaret; Edwards, Kevin; Sargent, Ruth; Coffey, Melissa; Murray, Karen; Young, Melissa; Mohan, Parvathi; Nair, Kavita; Diehl, Anna Mae; Gortfried, Marcia; Guy, Cynthia; Killenberg, Paul; Kwan, Samantha; Pan, Yi Ping; Piercy, Dawn; Smith, Melissa; Bhimalli, Prajakta; Chalasani, Naga; Cummings, Oscar; Lee, Lydia; Ragozzino, Linda; Vuppalanchi, Raj; Scheimann, Ann; Torbenson, Michael; Klipsch, Ann; Molleston, Jean; Subbarao, Girish; Barlow, Sarah; Derdoy, Jose; Hoffmann, Joyce; King, Debra; Siegner, Joan; Stewart, Susan; Tetri, Brent A.; Thompson, Judy; Behling, Cynthia; Celedon, Manual; Clark, Lisa; Durelle, Janis; Hassanein, Tarek; Lavine, Joel E.; Mendoza, Susana; Sirlin, Claude; Stein, Tanya; Tobin, Allison; Bambha, Kiran; Bass, Nathan M.; Ferrell, Linda D.; Filipowski, Danuta; Merriman, Raphael; Pabst, Mark; Rosenthal, Monique; Rosenthal, Philip; Steel, Tessa; Boyett, Sherry; Bryan, Daphne; Contos, Melissa J.; Fuchs, Michael; Graham, Martin; Jones, Amy; Luketic, Velimir A C; Sandhu, Bimalijit; Sanyal, Arun J.; Sargeant, Carol; Selph, Kimberly; White, Melanie; Gyurkey, Grace; Mooney, Jody; Nelson, James; Roberts, Sarah; Saunders, Cheryl; Stead, Alice; Wang, Chia; Yeh, Matthew; Brunt, Elizabeth; Kleiner, David; Grave, Gilman D.; Huang, Terry T K; Doo, Edward; Everhart, James E.; Hoofnagle, Jay H.; Robuck, Patricia R.; Seeff, Leonard; Belt, Patricia; Brancati, Fred; Clark, Jeanne; Colvin, Ryan; Donithan, Michele; Green, Mika; Hollick, Rosemary; Isaacson, Milana; Kim, Wana; Lydecker, Alison; Miriel, Laura; Sternberg, Alice; Tonascia, James; Van Natta, Mark; Wilson, Laura; Yates, Katherine.

In: Hepatology, Vol. 49, No. 6, 06.2009, p. 1904-1912.

Research output: Contribution to journalArticle

David, K, Kowdley, KV, Unalp, A, Kanwal, F, Brunt, EM, Schwimmer, JB, Abrams, S, Arceo, D, Espinosa, D, Fairly, L, McCullough, A, Bringman, D, Dasarathy, S, Hawkins, C, Liu, YC, Rogers, N, Stager, M, Edwards, K, Sargent, R, Coffey, M, Murray, K, Young, M, Mohan, P, Nair, K, Diehl, AM, Gortfried, M, Guy, C, Killenberg, P, Kwan, S, Pan, YP, Piercy, D, Smith, M, Bhimalli, P, Chalasani, N, Cummings, O, Lee, L, Ragozzino, L, Vuppalanchi, R, Scheimann, A, Torbenson, M, Klipsch, A, Molleston, J, Subbarao, G, Barlow, S, Derdoy, J, Hoffmann, J, King, D, Siegner, J, Stewart, S, Tetri, BA, Thompson, J, Behling, C, Celedon, M, Clark, L, Durelle, J, Hassanein, T, Lavine, JE, Mendoza, S, Sirlin, C, Stein, T, Tobin, A, Bambha, K, Bass, NM, Ferrell, LD, Filipowski, D, Merriman, R, Pabst, M, Rosenthal, M, Rosenthal, P, Steel, T, Boyett, S, Bryan, D, Contos, MJ, Fuchs, M, Graham, M, Jones, A, Luketic, VAC, Sandhu, B, Sanyal, AJ, Sargeant, C, Selph, K, White, M, Gyurkey, G, Mooney, J, Nelson, J, Roberts, S, Saunders, C, Stead, A, Wang, C, Yeh, M, Brunt, E, Kleiner, D, Grave, GD, Huang, TTK, Doo, E, Everhart, JE, Hoofnagle, JH, Robuck, PR, Seeff, L, Belt, P, Brancati, F, Clark, J, Colvin, R, Donithan, M, Green, M, Hollick, R, Isaacson, M, Kim, W, Lydecker, A, Miriel, L, Sternberg, A, Tonascia, J, Van Natta, M, Wilson, L & Yates, K 2009, 'Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network', Hepatology, vol. 49, no. 6, pp. 1904-1912. https://doi.org/10.1002/hep.22868
David, Kristin ; Kowdley, Kris V. ; Unalp, Aynur ; Kanwal, Fasiha ; Brunt, Elizabeth M. ; Schwimmer, Jeffrey B. ; Abrams, Stephanie ; Arceo, Diana ; Espinosa, Denise ; Fairly, Leanel ; McCullough, Arthur ; Bringman, Diane ; Dasarathy, Srinivasan ; Hawkins, Carol ; Liu, Yao Chang ; Rogers, Nicholette ; Stager, Margaret ; Edwards, Kevin ; Sargent, Ruth ; Coffey, Melissa ; Murray, Karen ; Young, Melissa ; Mohan, Parvathi ; Nair, Kavita ; Diehl, Anna Mae ; Gortfried, Marcia ; Guy, Cynthia ; Killenberg, Paul ; Kwan, Samantha ; Pan, Yi Ping ; Piercy, Dawn ; Smith, Melissa ; Bhimalli, Prajakta ; Chalasani, Naga ; Cummings, Oscar ; Lee, Lydia ; Ragozzino, Linda ; Vuppalanchi, Raj ; Scheimann, Ann ; Torbenson, Michael ; Klipsch, Ann ; Molleston, Jean ; Subbarao, Girish ; Barlow, Sarah ; Derdoy, Jose ; Hoffmann, Joyce ; King, Debra ; Siegner, Joan ; Stewart, Susan ; Tetri, Brent A. ; Thompson, Judy ; Behling, Cynthia ; Celedon, Manual ; Clark, Lisa ; Durelle, Janis ; Hassanein, Tarek ; Lavine, Joel E. ; Mendoza, Susana ; Sirlin, Claude ; Stein, Tanya ; Tobin, Allison ; Bambha, Kiran ; Bass, Nathan M. ; Ferrell, Linda D. ; Filipowski, Danuta ; Merriman, Raphael ; Pabst, Mark ; Rosenthal, Monique ; Rosenthal, Philip ; Steel, Tessa ; Boyett, Sherry ; Bryan, Daphne ; Contos, Melissa J. ; Fuchs, Michael ; Graham, Martin ; Jones, Amy ; Luketic, Velimir A C ; Sandhu, Bimalijit ; Sanyal, Arun J. ; Sargeant, Carol ; Selph, Kimberly ; White, Melanie ; Gyurkey, Grace ; Mooney, Jody ; Nelson, James ; Roberts, Sarah ; Saunders, Cheryl ; Stead, Alice ; Wang, Chia ; Yeh, Matthew ; Brunt, Elizabeth ; Kleiner, David ; Grave, Gilman D. ; Huang, Terry T K ; Doo, Edward ; Everhart, James E. ; Hoofnagle, Jay H. ; Robuck, Patricia R. ; Seeff, Leonard ; Belt, Patricia ; Brancati, Fred ; Clark, Jeanne ; Colvin, Ryan ; Donithan, Michele ; Green, Mika ; Hollick, Rosemary ; Isaacson, Milana ; Kim, Wana ; Lydecker, Alison ; Miriel, Laura ; Sternberg, Alice ; Tonascia, James ; Van Natta, Mark ; Wilson, Laura ; Yates, Katherine. / Quality of life in adults with nonalcoholic fatty liver disease : Baseline data from the nonalcoholic steatohepatitis clinical research network. In: Hepatology. 2009 ; Vol. 49, No. 6. pp. 1904-1912.
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title = "Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network",
abstract = "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61{\%} had definite nonalcoholic steatohepatitis (NASH), and 28{\%} had bridging fibrosis or cirrhosis. Diabetes was present in 27{\%} of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.",
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month = "6",
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language = "English",
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pages = "1904--1912",
journal = "Hepatology",
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TY - JOUR

T1 - Quality of life in adults with nonalcoholic fatty liver disease

T2 - Baseline data from the nonalcoholic steatohepatitis clinical research network

AU - David, Kristin

AU - Kowdley, Kris V.

AU - Unalp, Aynur

AU - Kanwal, Fasiha

AU - Brunt, Elizabeth M.

AU - Schwimmer, Jeffrey B.

AU - Abrams, Stephanie

AU - Arceo, Diana

AU - Espinosa, Denise

AU - Fairly, Leanel

AU - McCullough, Arthur

AU - Bringman, Diane

AU - Dasarathy, Srinivasan

AU - Hawkins, Carol

AU - Liu, Yao Chang

AU - Rogers, Nicholette

AU - Stager, Margaret

AU - Edwards, Kevin

AU - Sargent, Ruth

AU - Coffey, Melissa

AU - Murray, Karen

AU - Young, Melissa

AU - Mohan, Parvathi

AU - Nair, Kavita

AU - Diehl, Anna Mae

AU - Gortfried, Marcia

AU - Guy, Cynthia

AU - Killenberg, Paul

AU - Kwan, Samantha

AU - Pan, Yi Ping

AU - Piercy, Dawn

AU - Smith, Melissa

AU - Bhimalli, Prajakta

AU - Chalasani, Naga

AU - Cummings, Oscar

AU - Lee, Lydia

AU - Ragozzino, Linda

AU - Vuppalanchi, Raj

AU - Scheimann, Ann

AU - Torbenson, Michael

AU - Klipsch, Ann

AU - Molleston, Jean

AU - Subbarao, Girish

AU - Barlow, Sarah

AU - Derdoy, Jose

AU - Hoffmann, Joyce

AU - King, Debra

AU - Siegner, Joan

AU - Stewart, Susan

AU - Tetri, Brent A.

AU - Thompson, Judy

AU - Behling, Cynthia

AU - Celedon, Manual

AU - Clark, Lisa

AU - Durelle, Janis

AU - Hassanein, Tarek

AU - Lavine, Joel E.

AU - Mendoza, Susana

AU - Sirlin, Claude

AU - Stein, Tanya

AU - Tobin, Allison

AU - Bambha, Kiran

AU - Bass, Nathan M.

AU - Ferrell, Linda D.

AU - Filipowski, Danuta

AU - Merriman, Raphael

AU - Pabst, Mark

AU - Rosenthal, Monique

AU - Rosenthal, Philip

AU - Steel, Tessa

AU - Boyett, Sherry

AU - Bryan, Daphne

AU - Contos, Melissa J.

AU - Fuchs, Michael

AU - Graham, Martin

AU - Jones, Amy

AU - Luketic, Velimir A C

AU - Sandhu, Bimalijit

AU - Sanyal, Arun J.

AU - Sargeant, Carol

AU - Selph, Kimberly

AU - White, Melanie

AU - Gyurkey, Grace

AU - Mooney, Jody

AU - Nelson, James

AU - Roberts, Sarah

AU - Saunders, Cheryl

AU - Stead, Alice

AU - Wang, Chia

AU - Yeh, Matthew

AU - Brunt, Elizabeth

AU - Kleiner, David

AU - Grave, Gilman D.

AU - Huang, Terry T K

AU - Doo, Edward

AU - Everhart, James E.

AU - Hoofnagle, Jay H.

AU - Robuck, Patricia R.

AU - Seeff, Leonard

AU - Belt, Patricia

AU - Brancati, Fred

AU - Clark, Jeanne

AU - Colvin, Ryan

AU - Donithan, Michele

AU - Green, Mika

AU - Hollick, Rosemary

AU - Isaacson, Milana

AU - Kim, Wana

AU - Lydecker, Alison

AU - Miriel, Laura

AU - Sternberg, Alice

AU - Tonascia, James

AU - Van Natta, Mark

AU - Wilson, Laura

AU - Yates, Katherine

PY - 2009/6

Y1 - 2009/6

N2 - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.

AB - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.

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U2 - 10.1002/hep.22868

DO - 10.1002/hep.22868

M3 - Article

VL - 49

SP - 1904

EP - 1912

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 6

ER -