Quantification of biochemical markers of bone turnover by kinetic measures of bone formation and resorption in young healthy females

Connie M. Weaver, Munro Peacock, Berdine R. Martin, George P. Mccabe, Jian Zhao, David L. Smith, Meryl E. Wastney

Research output: Contribution to journalArticle

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Abstract

The quantification of biochemical markers of bone formation and resorption with kinetic measures of bone turnover is an essential step in their validation. Some biochemical markers have been validated by quantification against formation and resorption rates measured by calcium kinetics in adults with bone disease. However, none has been validated in healthy individuals who are undergoing skeletal growth and bone consolidation. Therefore, we have measured biochemical markers of bone formation (serum osteocalcin [OC], bone-specific alkaline phosphatase [BAP], and total alkaline phosphatase [ALP]) and resorption (serum tartrate resistant acid phosphatase [TRAP], urinary cross-linked N teleopeptides of type I collagen/creatinine [NTx/Cr], and hydroxyproline/creatinine [OHP/Cr]) in healthy females aged 11-32 years (n = 31) after an overnight fast to determine their relationship with bone formation (Vo+) and bone resorption (Vo-) as measured by calcium kinetics and balance. All biochemical markers were highly intercorrelated (r > 0.6, p < 0.001) as were Vo+ and Vo- (r = 0.91, p < 0.001). Highly significant correlations were present between bone formation measured by calcium kinetics (Vo+) and serum levels of bone biochemical markers (OC, r = 0.82, p = 0.001; ALP, r = 0.92, p = 0.001; and BAP, r = 0.90, p = 0.001) and between bone resorption measured by calcium kinetics (Vo-) and fasting serum levels and urine creatinine ratios of biochemical markers (TRAP, r = 0.77, p < 0.001; OHP/Cr, r = 0.79, p < 0.001; and NTx/Cr, r = 0.70, p < 0.001). Thus, biochemical markers of bone formation and resorption can be used to predict calcium kinetic rates during skeletal growth and the early years of formation of peak bone mass, ages at which strategies to build peak bone mass are important. Biochemical markers of formation and resorption are equally useful in predicting either the bone formation rate or the resorption rate.

Original languageEnglish
Pages (from-to)1714-1720
Number of pages7
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume12
Issue number10
DOIs
StatePublished - Oct 1997

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Bone Remodeling
Bone Resorption
Osteogenesis
Biomarkers
Alkaline Phosphatase
Calcium
Bone and Bones
Creatinine
Osteocalcin
Serum
Bone Diseases
Bone Development
Hydroxyproline
Collagen Type I
Fasting
Urine
Growth

ASJC Scopus subject areas

  • Surgery

Cite this

Quantification of biochemical markers of bone turnover by kinetic measures of bone formation and resorption in young healthy females. / Weaver, Connie M.; Peacock, Munro; Martin, Berdine R.; Mccabe, George P.; Zhao, Jian; Smith, David L.; Wastney, Meryl E.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 12, No. 10, 10.1997, p. 1714-1720.

Research output: Contribution to journalArticle

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AU - Zhao, Jian

AU - Smith, David L.

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