Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography

Pilar Herrero, Joanne Markham, Carla J. Weinheimer, Carolyn J. Anderson, Michael J. Welch, Mark Green, Steven R. Bergmann

Research output: Contribution to journalArticle

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Abstract

Background. Noninvasive assessment of regional myocardial perfusion at rest and after stress is important for the objective evaluation of the effects of coronary artery disease and its response to therapy. Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission tomography (PET). The aim of the present study was to develop and implement an approach to quantify regional myocardial perfusion using copper(II) pyruvaldehyde bis-(N4-thiosemicarbazone) (PTSM) labeled with the generator-produced, positron-emitting radionuclide 62Cu (t1/2=9.7 minutes). Methods and Results. Regional perfusion was estimated from dynamic PET scans after intravenous administration of 62Cu-PTSM in 21 studies in 13 intact dogs evaluated over a wide range of myocardial flow values. In 15 interventions in nine dogs, regional perfusion was also estimated with H215O. Regional perfusion with 62Cu-PTSM was estimated from dynamic blood and tissue time-activity curves, along with the model parameter k1 (forward rate of transport) and the PET parameter FBM (fraction of blood pool activity observed in tissue), using a two-compartment kinetic model. Arterial blood activity was corrected for red blood cell-associated 62Cu. In 44 comparisons, estimates of regional perfusion with 62Cu-PTSM correlated well with estimates obtained with concomitantly administered radiolabeled microspheres (y=0.90x±0.15, r=0.95, p215O and 62Cu-PTSM, regional perfusion estimated with 62Cu-PTSM was not significantly different from that obtained with H215O (1.05±0.36 versus 0.96±0.28 ml/g per minute). 62Cu-PTSM provided high-quality images of the heart. Conclusions. The results of this study demonstrate that quantification of regional myocardial perfusion is feasible using generator-produced 62Cu-PTSM. Since 62Cu-PTSM can be used to estimate perfusion in the brain, kidney, and tumors as well as in the heart, it is an attractive tracer for centers that rely on generator-produced tracers for the evaluation of perfusion with PET.

Original languageEnglish (US)
Pages (from-to)173-183
Number of pages11
JournalCirculation
Volume87
Issue number1
StatePublished - Jan 1993
Externally publishedYes

Fingerprint

Thiosemicarbazones
Pyruvaldehyde
Positron-Emission Tomography
Perfusion
Radionuclide Generators
Dogs
Cyclotrons
Microspheres
Brain Neoplasms
Radioisotopes
Intravenous Administration
Copper
Coronary Artery Disease
Erythrocytes

Keywords

  • Blood flow, myocardial
  • Modeling, mathematical
  • Radionuclides
  • Radiotracers

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Herrero, P., Markham, J., Weinheimer, C. J., Anderson, C. J., Welch, M. J., Green, M., & Bergmann, S. R. (1993). Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography. Circulation, 87(1), 173-183.

Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography. / Herrero, Pilar; Markham, Joanne; Weinheimer, Carla J.; Anderson, Carolyn J.; Welch, Michael J.; Green, Mark; Bergmann, Steven R.

In: Circulation, Vol. 87, No. 1, 01.1993, p. 173-183.

Research output: Contribution to journalArticle

Herrero, P, Markham, J, Weinheimer, CJ, Anderson, CJ, Welch, MJ, Green, M & Bergmann, SR 1993, 'Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography', Circulation, vol. 87, no. 1, pp. 173-183.
Herrero P, Markham J, Weinheimer CJ, Anderson CJ, Welch MJ, Green M et al. Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography. Circulation. 1993 Jan;87(1):173-183.
Herrero, Pilar ; Markham, Joanne ; Weinheimer, Carla J. ; Anderson, Carolyn J. ; Welch, Michael J. ; Green, Mark ; Bergmann, Steven R. / Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography. In: Circulation. 1993 ; Vol. 87, No. 1. pp. 173-183.
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abstract = "Background. Noninvasive assessment of regional myocardial perfusion at rest and after stress is important for the objective evaluation of the effects of coronary artery disease and its response to therapy. Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission tomography (PET). The aim of the present study was to develop and implement an approach to quantify regional myocardial perfusion using copper(II) pyruvaldehyde bis-(N4-thiosemicarbazone) (PTSM) labeled with the generator-produced, positron-emitting radionuclide 62Cu (t1/2=9.7 minutes). Methods and Results. Regional perfusion was estimated from dynamic PET scans after intravenous administration of 62Cu-PTSM in 21 studies in 13 intact dogs evaluated over a wide range of myocardial flow values. In 15 interventions in nine dogs, regional perfusion was also estimated with H215O. Regional perfusion with 62Cu-PTSM was estimated from dynamic blood and tissue time-activity curves, along with the model parameter k1 (forward rate of transport) and the PET parameter FBM (fraction of blood pool activity observed in tissue), using a two-compartment kinetic model. Arterial blood activity was corrected for red blood cell-associated 62Cu. In 44 comparisons, estimates of regional perfusion with 62Cu-PTSM correlated well with estimates obtained with concomitantly administered radiolabeled microspheres (y=0.90x±0.15, r=0.95, p215O and 62Cu-PTSM, regional perfusion estimated with 62Cu-PTSM was not significantly different from that obtained with H215O (1.05±0.36 versus 0.96±0.28 ml/g per minute). 62Cu-PTSM provided high-quality images of the heart. Conclusions. The results of this study demonstrate that quantification of regional myocardial perfusion is feasible using generator-produced 62Cu-PTSM. Since 62Cu-PTSM can be used to estimate perfusion in the brain, kidney, and tumors as well as in the heart, it is an attractive tracer for centers that rely on generator-produced tracers for the evaluation of perfusion with PET.",
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AU - Herrero, Pilar

AU - Markham, Joanne

AU - Weinheimer, Carla J.

AU - Anderson, Carolyn J.

AU - Welch, Michael J.

AU - Green, Mark

AU - Bergmann, Steven R.

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N2 - Background. Noninvasive assessment of regional myocardial perfusion at rest and after stress is important for the objective evaluation of the effects of coronary artery disease and its response to therapy. Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission tomography (PET). The aim of the present study was to develop and implement an approach to quantify regional myocardial perfusion using copper(II) pyruvaldehyde bis-(N4-thiosemicarbazone) (PTSM) labeled with the generator-produced, positron-emitting radionuclide 62Cu (t1/2=9.7 minutes). Methods and Results. Regional perfusion was estimated from dynamic PET scans after intravenous administration of 62Cu-PTSM in 21 studies in 13 intact dogs evaluated over a wide range of myocardial flow values. In 15 interventions in nine dogs, regional perfusion was also estimated with H215O. Regional perfusion with 62Cu-PTSM was estimated from dynamic blood and tissue time-activity curves, along with the model parameter k1 (forward rate of transport) and the PET parameter FBM (fraction of blood pool activity observed in tissue), using a two-compartment kinetic model. Arterial blood activity was corrected for red blood cell-associated 62Cu. In 44 comparisons, estimates of regional perfusion with 62Cu-PTSM correlated well with estimates obtained with concomitantly administered radiolabeled microspheres (y=0.90x±0.15, r=0.95, p215O and 62Cu-PTSM, regional perfusion estimated with 62Cu-PTSM was not significantly different from that obtained with H215O (1.05±0.36 versus 0.96±0.28 ml/g per minute). 62Cu-PTSM provided high-quality images of the heart. Conclusions. The results of this study demonstrate that quantification of regional myocardial perfusion is feasible using generator-produced 62Cu-PTSM. Since 62Cu-PTSM can be used to estimate perfusion in the brain, kidney, and tumors as well as in the heart, it is an attractive tracer for centers that rely on generator-produced tracers for the evaluation of perfusion with PET.

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