Quantifying skin photodamage with spatial frequency domain imaging: Statistical results

Jeffrey B. Travers, Chien Poon, Trevor Bihl, Benjamin Rinehart, Christina Borchers, Daniel J. Rohrbach, Samia Borchers, Julian Trevino, Max Rubin, Heidi Donnelly, Karl Kellawan, Lydia Carpenter, Shalini Bahl, Craig Rohan, Elizabeth Muennich, Scott Guenthner, Holly Hahn, Ali Rkein, Marc Darst, Nico MousdicasElizabeth Cates, Ulas Sunar

Research output: Contribution to journalArticle

1 Scopus citations


We investigated the change in optical properties and vascular parameters to characterize skin tissue from mild photodamage to actinic keratosis (AK) with comparison to a published photodamage scale. Multi-wavelength spatial frequency domain imaging (SFDI) measurements were performed on the dorsal forearms of 55 adult subjects with various amounts of photodamage. Dermatologists rated the levels of photodamage based upon the photographs in blinded fashion to allow comparison with SFDI data. For characterization of statistical data, we used artificial neural networks. Our results indicate that optical and vascular parameters can be used to quantify photodamage and can discriminate between the stages as low, medium, and high grades, with the best performance of ∼70%, ∼76% and 80% for characterization of low- medium- and high-grade lesions, respectively. Ultimately, clinicians can use this noninvasive approach for risk assessment and frequent monitoring of high-risk populations.

Original languageEnglish (US)
Pages (from-to)4676-4683
Number of pages8
JournalBiomedical Optics Express
Issue number9
StatePublished - Sep 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Quantifying skin photodamage with spatial frequency domain imaging: Statistical results'. Together they form a unique fingerprint.

  • Cite this

    Travers, J. B., Poon, C., Bihl, T., Rinehart, B., Borchers, C., Rohrbach, D. J., Borchers, S., Trevino, J., Rubin, M., Donnelly, H., Kellawan, K., Carpenter, L., Bahl, S., Rohan, C., Muennich, E., Guenthner, S., Hahn, H., Rkein, A., Darst, M., ... Sunar, U. (2019). Quantifying skin photodamage with spatial frequency domain imaging: Statistical results. Biomedical Optics Express, 10(9), 4676-4683. https://doi.org/10.1364/BOE.10.004676