Abstract
The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls. Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated infants and toddlers; 38 CLDI were compared with 39 full-term controls. For CLDI subjects, gestational age at birth ranged from 25 to 29 weeks. Airway size was measured for the trachea and the next three to four generations into the right lower lobe; lung volumes and tissue density were also measured. The relationship between airway size and airway generation differed between the CLDI and full-term groups; the sizes of the first and second airway generations were larger in the shorter CLDI than in the shorter full-term subjects. The increased size in the airways in the CLDI subjects was associated with increasing mechanical ventilation time in the neonatal period. CLDI subjects had a greater heterogeneity of lung density compared with full-term subjects. Our results indicate that quantitative analysis of multi-slice CT scans at elevated volumes provides important insights into the pulmonary pathology of infants and toddlers with CLDI. Copyright
| Original language | English |
|---|---|
| Pages (from-to) | 992-999 |
| Number of pages | 8 |
| Journal | European Respiratory Journal |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2012 |
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Keywords
- Bronchopulmonary dysplasia
- High-resolution computed tomography
- Lung development
- Lung volume measurement
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Quantitative assessment of chronic lung disease of infancy using computed tomography. / Sarria, E. E.; Mattiello, R.; Rao, L.; Tiller, C. J.; Poindexter, B.; Applegate, K. E.; Granroth-Cook, J.; Denski, C.; Nguyen, J.; Yu, Zhangsheng; Hoffman, E.; Tepper, Robert.
In: European Respiratory Journal, Vol. 39, No. 4, 01.04.2012, p. 992-999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative assessment of chronic lung disease of infancy using computed tomography
AU - Sarria, E. E.
AU - Mattiello, R.
AU - Rao, L.
AU - Tiller, C. J.
AU - Poindexter, B.
AU - Applegate, K. E.
AU - Granroth-Cook, J.
AU - Denski, C.
AU - Nguyen, J.
AU - Yu, Zhangsheng
AU - Hoffman, E.
AU - Tepper, Robert
PY - 2012/4/1
Y1 - 2012/4/1
N2 - The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls. Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated infants and toddlers; 38 CLDI were compared with 39 full-term controls. For CLDI subjects, gestational age at birth ranged from 25 to 29 weeks. Airway size was measured for the trachea and the next three to four generations into the right lower lobe; lung volumes and tissue density were also measured. The relationship between airway size and airway generation differed between the CLDI and full-term groups; the sizes of the first and second airway generations were larger in the shorter CLDI than in the shorter full-term subjects. The increased size in the airways in the CLDI subjects was associated with increasing mechanical ventilation time in the neonatal period. CLDI subjects had a greater heterogeneity of lung density compared with full-term subjects. Our results indicate that quantitative analysis of multi-slice CT scans at elevated volumes provides important insights into the pulmonary pathology of infants and toddlers with CLDI. Copyright
AB - The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls. Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated infants and toddlers; 38 CLDI were compared with 39 full-term controls. For CLDI subjects, gestational age at birth ranged from 25 to 29 weeks. Airway size was measured for the trachea and the next three to four generations into the right lower lobe; lung volumes and tissue density were also measured. The relationship between airway size and airway generation differed between the CLDI and full-term groups; the sizes of the first and second airway generations were larger in the shorter CLDI than in the shorter full-term subjects. The increased size in the airways in the CLDI subjects was associated with increasing mechanical ventilation time in the neonatal period. CLDI subjects had a greater heterogeneity of lung density compared with full-term subjects. Our results indicate that quantitative analysis of multi-slice CT scans at elevated volumes provides important insights into the pulmonary pathology of infants and toddlers with CLDI. Copyright
KW - Bronchopulmonary dysplasia
KW - High-resolution computed tomography
KW - Lung development
KW - Lung volume measurement
UR - http://www.scopus.com/inward/record.url?scp=84860324605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860324605&partnerID=8YFLogxK
U2 - 10.1183/09031936.00064811
DO - 10.1183/09031936.00064811
M3 - Article
C2 - 22005925
AN - SCOPUS:84860324605
VL - 39
SP - 992
EP - 999
JO - European Respiratory Journal
JF - European Respiratory Journal
SN - 0903-1936
IS - 4
ER -