Quantitative comparison of functional contrast from BOLD-weighted spin-echo and gradient-echo echoplanar imaging at 1.5 Tesla and H215O PET in the whole brain

M. J. Lowe, J. T. Lurito, V. P. Mathews, M. D. Phillips, G. D. Hutchins

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Spin-echo and gradient-echo echoplanar functional magnetic resonance imaging (fMRI) studies at 1.5 Tesla (T) were used to obtain blood oxygenation level-dependent (BOLD) contrast images of the whole brain in seven strongly right-handed women during execution of a complex motor task. Five subjects underwent subsequent H215O positron emission tomography (PET) studies while performing the same task. Group-averaged results for changes in the MRI relaxation rates R2* and R2 at 1.5T in response to neuronal activation in nine cortical, subcortical, and cerebellar motor regions are reported. Results for each method are grouped according to tissue type - cerebral cortex (precentral gyrus and supplementary motor area), subcortical regions (thalamus and putamen), and cerebellar cortex (superior lobule). The observed changes in R2* from activation-induced oxygenation changes were more variable across brain regions with different tissue characteristics than observed changes in R2. The ratio of ΔR2 to ΔR2 was 3.3 ± 0.9 for cerebral cortex and 2.0 ± 0.6 for subcortical tissue. ΔR2* ΔR2, and relative blood flow changes were ΔR2* = -0.201 ± 0.040 s-1, ΔR2 = -0.064 ± 0.011 s-1, and Δf/f = 16.7 ± 0.8% in the cerebral cortex; ΔR2* = -0.100 ± 0.026 s-1, ΔR2 = -0.049 ± 0.009 s-1, and Δf/f = 9.4 ± 0.7% in the subcortical regions; and ΔR2* = -0.215 ± 0.093 s-1, ΔR2 = -0.069 ± 0.012 s-1, and Δf/f = 16.2 ± 1.2% in the cerebellar cortex.

Original languageEnglish (US)
Pages (from-to)1331-1340
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume20
Issue number9
DOIs
StatePublished - Jan 1 2000

Keywords

  • Basal ganglia
  • Cerebellum
  • Functional magnetic resonance imagin
  • Motor cortex
  • Positron emission tomography
  • Spin-echo imaging

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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